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FLASH GENE
Symbol PFKFB2 contributors: - updated : 17-03-2006
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
HGNC id 8873
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ATP binding site
  • two fructose-6-phosphate binding site
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to chimpanzee pfkfb2
    ortholog to rattus Pfkfb2
    ortholog to murine Pfkfb2
    Homologene
    FAMILY
  • phosphoglycerate mutase family, in the C-terminal section
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a 6-phosphofructo-2-kinase
  • acting as a fructose 2,6-biphosphatase 2
  • involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • synthesis and degradation of fructose 2,6-bisphosphate
  • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • ATP
  • fructose-6-phosphate
  • protein
    cell & other
    REGULATION
    activated by phosphorylation, for the kinase activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS