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FLASH GENE
Symbol PFKFB2 contributors: mct - updated : 08-06-2021
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
HGNC id 8873
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
significantly higher in hepatocellular carcinoma than in the corresponding nontumor tissues
constitutional     --over  
in placentas from pregnancies with IUGR
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
  • PFKFB2 promoter methylation analysis has potential applicability to better stratify WDTC patients according to the recurrence risk
  • Therapy target
    ANIMAL & CELL MODELS