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FLASH GENE
Symbol NME1 contributors: mct/npt/pgu - updated : 17-01-2013
HGNC name non-metastatic cells 1, protein (NM23A) expressed in
HGNC id 7849
Location 17q21.33      Physical location : 49.230.919 - 49.239.450
Synonym name
  • tumor metastasis suppressor
  • nucleoside-diphosphate kinase 1
  • granzyme A-activated DNase
  • Synonym symbol(s) NDPK, NM23-H1, NM23, AWD, GAAD, NDPKA, NDPK-A
    EC.number 2.7.4.6
    DNA
    TYPE functioning gene
    STRUCTURE 8.53 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked Y status confirmed
    Map cen - 5' - NME1 - D17S396 - NME2 - 3' - qter
    Physical map
    FLJ33318 17q21.33 hypothetical protein FLJ33318 XYLT2 17q21.3-17q22 xylosyltransferase II MRPL27 17q21.3-q22 mitochondrial ribosomal protein L27 FLJ31364 PRO1855 17q21.33 hypothetical protein PRO1855 FLJ20920 17q21.33 hypothetical protein FLJ20920 MRPS21P9 17q21 mitochondrial ribosomal protein S21 pseudogene 9 CHAD 17q21.33 chondroadherin FLJ11164 17q21.33 hypothetical protein FLJ11164 DKFZp434N1415 17q21.33 Mycbp-associated protein EPN3 17q24.1 epsin 3 FLJ21347 17q21.33 hypothetical protein FLJ21347 LOC253962 17q21.33 hypothetical protein LOC253962 CACNA1G 17q22 calcium channel, voltage-dependent, alpha 1G subunit ABCC3 17q21.3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 MGC15396 17q21.33 hypothetical protein MGC15396 LUC7A 17q21 cisplatin resistance-associated overexpressed protein OA48-18 17q21.33 acid-inducible phosphoprotein FLJ20694 17q21.33 hypothetical protein FLJ20694 LOC390801 17 similar to S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II ligand, calpactin I, light polypeptide WFIKKNRP 17q21.33 WFIKKN-related protein LOC390802 17 similar to ribosomal protein L5; 60S ribosomal protein L5 TOB1 17q21 transducer of ERBB2, 1 SPAG9 17q21.31 sperm associated antigen 9 NME1 17q21.31 non-metastatic cells 1, protein (NM23A) expressed in NME2 17q21.31 non-metastatic cells 2, protein (NM23B) expressed in MBTD1 17q24.1 mbt domain containing 1 CGI-48 17q21.33 CGI-48 protein LOC388401 17 similar to ribosomal protein L7 CA10 17q24 carbonic anhydrase X
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1031 - 177 - 2008 18635542
  • NME1IA
  • isoform soluble
  • 5 - 811 - 152 - 2008 18635542
  • NME1IB
  • associated with the soluble as well as membranous fraction
  • - - - - - - 2008 18635542
    mitochondrial isoform ,in the pancreatic beta cell mitochondrial subfraction
    - splicing - - - - - 24811176
  • only NME1L interacts with IKBKB
  • is a potent antimetastatic protein and may be a useful weapon in the fight against cancers
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     pharynx   highly
     salivary gland   highly
    Reproductivefemale systembreastmammary gland highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines lung carcinoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain
  • a C terminal extension preceded by the YEEEEP motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • NM23 nucleoside diphosphate kinase gene family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • pyrimidine biosynthetic pathway, involved in the phosphorylation of nucleoside diphosphates
  • selectively regulates the PRKAA1, independently of the AMP concentration such that the manipulation of NME1 nucleotide trans-phosphorylation activity to generate ATP enhanced the activity of PRKAA1
  • involved in the regulation of many cellular processes as well as in tumor metastasis
  • involved in epidermal homeostasis which depends on a tight regulation of the levels of NME1 isoforms
  • can negatively regulate cell migration and tumor metastasis by modulating the activity of CDC42 and possibly other Rho family members through interaction with MCF2
  • having a 3prime-5prime exonuclease activity necessary for metastasis suppressor function
  • tumor metastasis suppressor, which functions as a nucleoside-diphosphate kinase converting nucleoside diphosphates to nucleoside triphosphates with an expense of ATP
  • may have a role in the regulation of cell cycle and apoptosis in human B-cells
  • loss of NME1, an event suspected to promote metastasis, may additionally function at an earlier stage of tumor development to drive the acquisition of chromosomal instability
  • critical for control of cell-cell adhesion and cell migration at early stages of the invasive program in epithelial cancers, orchestrating a barrier against conversion of in situ carcinoma into invasive malignancy
  • critical role for NME1 isoforms in limiting mutagenesis and suppressing UV radiation -induced melanomagenesis
  • exists in a functional cellular complex with PRKAA1 and CFTR in airway epithelia, and its catalytic function is required for the PRKAA1-dependent regulation of CFTR
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with SCS(succinyl-coA-synthetase)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MEN1, SCS
  • interacting with TUBB, TUBG1, VIM
  • interaction partner of PRUNE
  • IFI16 and NME1 are simultaneously bound to the same DNA fragments, suggesting their common involvement in the reduced development of some tumors
  • TXNRD1 is an interacting protein of NME1, and it binds specifically to oxidized NME1
  • TSLP might downregulate NME1 expression via STAT3 signaling pathway, affecting TIMP1 expression in influencing trophoblast invasion
  • cell & other
    REGULATION
    inhibited by of NME1 expression by TSLP was completely abrogated by STAT3 inhibitor
    Other key enzymatic and metastasis suppressor functions of NME1 are regulated by oxido-reduction of its Cys109
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    mutated in agressive neuroblastoma with a reduced expression in tumor progression to the metastatic phenotype
    tumoral     --over  
    in neuroblastoma
    tumoral     --low  
    associated with aggressive forms of multiple cancers
    tumoral     --other  
    its expression is associated with poor prognosis in peripheral T-cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS