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FLASH GENE
Symbol NME2 contributors: mct/ - updated : 19-12-2017
HGNC name non-metastatic cells 2, protein (NM23B) expressed in
HGNC id 7850
Location 17q21.33      Physical location : 49.242.890 - 49.249.104
Synonym name
  • c-myc transcription factor
  • C-myc purine-binding transcription factor PUF
  • NDP kinase B
  • nucleoside diphosphate kinase B
  • Synonym symbol(s) NM23-H2, NDPKB, NM23B, puf, MGC11121
    EC.number 2.7.4.6
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text the neighboring upstream gene of NME1
    STRUCTURE 6.22 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - NME1- NME2 - qter
    Authors Chandrasekharappa (93)
    Physical map
    FLJ33318 17q21.33 hypothetical protein FLJ33318 XYLT2 17q21.3-17q22 xylosyltransferase II MRPL27 17q21.3-q22 mitochondrial ribosomal protein L27 FLJ31364 PRO1855 17q21.33 hypothetical protein PRO1855 FLJ20920 17q21.33 hypothetical protein FLJ20920 MRPS21P9 17q21 mitochondrial ribosomal protein S21 pseudogene 9 CHAD 17q21.33 chondroadherin FLJ11164 17q21.33 hypothetical protein FLJ11164 DKFZp434N1415 17q21.33 Mycbp-associated protein EPN3 17q24.1 epsin 3 FLJ21347 17q21.33 hypothetical protein FLJ21347 LOC253962 17q21.33 hypothetical protein LOC253962 CACNA1G 17q22 calcium channel, voltage-dependent, alpha 1G subunit ABCC3 17q21.3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 MGC15396 17q21.33 hypothetical protein MGC15396 LUC7A 17q21 cisplatin resistance-associated overexpressed protein OA48-18 17q21.33 acid-inducible phosphoprotein FLJ20694 17q21.33 hypothetical protein FLJ20694 LOC390801 17 similar to S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II ligand, calpactin I, light polypeptide WFIKKNRP 17q21.33 WFIKKN-related protein LOC390802 17 similar to ribosomal protein L5; 60S ribosomal protein L5 TOB1 17q21 transducer of ERBB2, 1 SPAG9 17q21.31 sperm associated antigen 9 NME1 17q21.31 non-metastatic cells 1, protein (NM23A) expressed in NME2 17q21.31 non-metastatic cells 2, protein (NM23B) expressed in MBTD1 17q24.1 mbt domain containing 1 CGI-48 17q21.33 CGI-48 protein LOC388401 17 similar to ribosomal protein L7 CA10 17q24 carbonic anhydrase X
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 822 17.16 152 - Rochdi (2004)
    5 - 810 17.16 152 - Rochdi (2004)
    4 - 763 17.16 152 - Rochdi (2004)
    5 - 702 17.16 152 - Rochdi (2004)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     pharynx   highly
     salivary gland   highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines erythroleukemia lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain
  • a C terminal extension preceded by the YEEEEP motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • nm23 nucleoside diphosphate kinase gene (NDK) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the phosphorylation of nucleoside diphosphates
  • acting as a transcription regulator for myc
  • interacting with membrane receptor and constituting a novel molecular regulatory mechanism of GPCR endocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    pyrimidine biosynthetic pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ITGB1BP1
  • regulating the expression of MYC, PDGFA, and gelatinase A
  • complexing with Gbetagamma dimers contributing to G protein activation
  • interaction of HERC5 with the metastasis suppressor NME2 (Hochrainer 2008)
  • PGAM5 functions as a phosphohistidine phosphatase that specifically associates with and dephosphorylates the catalytic histidine on NME2
  • by dephosphorylating NME2, PGAM5 negatively regulates CD4(+) T cells by inhibiting NME2-mediated histidine phosphorylation and activation of the KCNN4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma, lung tumors, thyroid carcinoma with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene for malignant pleural mesothelioma
    Marker
    Therapy target
    ANIMAL & CELL MODELS