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FLASH GENE
Symbol NFIC contributors: mct - updated : 10-01-2024
HGNC name nuclear factor I/C (CCAAT-binding transcription factor)
HGNC id 7786
Location 19p13.3      Physical location : 3.359.615 - 3.463.602
Synonym name
  • CCAAT-binding transcription factor
  • nuclear factor 1 C-type
  • Synonym symbol(s) EVI158, CTF, NFI, CTF5, MGC20153
    DNA
    TYPE functioning gene
    STRUCTURE 109.59 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 8001 - 499 - 2023 37353485
    10 - 7847 - 430 - 2023 37353485
    11 - 8029 - 508 - 2023 37353485
    10 - 7875 - 439 - 2023 37353485
    9 - 7789 - 428 - 2023 37353485
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Digestivemouthtooth    Homo sapiens
    Endocrinepancreas   moderately
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveameloblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one DWA/MH1 domain
  • a CTF/NF-i DNA-binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Nfic
    Homologene
    FAMILY CTF/NFI family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2
  • involved in stimulating the initiation of adenovirus DNA replication and the activation of transcription driven by RNA polymerase II
  • NFIC acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in bone marrow stromal cells (BMSCs)
  • implicated in the regulation of tooth root development, where it may be anticipated to impact on the behavior of stem cells from the apical papilla (SCAPs) and root odontoblast activity
  • upregulation of NFIC activity in SCAPs may promote osteo/odontoblastic differentiation of SCAPs
  • plays critical roles in the regulation of tooth development by influencing the biological behaviors of stem cells in the dental germ
  • upregulation of NFIC may promote the proliferation and osteogenic/cementogenic differentiation of dental follicle cells (DFCs)
  • is an important transcription factor in myeloid differentiation as well as AML cell survival
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RUNX2-NFIC-SP7 pathway is one of the key factors that regulate ameloblast differentiation
  • a component
  • INTERACTION
    DNA binds DNA as a homodimer
    RNA
    small molecule
    protein
  • NF1C is a candidate to regulate AHR transcription in a polymorphism-dependent manner
  • NFIC directly binds to the promoter of low-density lipoprotein receptor-related protein 5 (LRP5) and thereafter transactivates the promoter
  • NFIC may contribute to postnatal chondrocyte proliferation by inhibiting CDKN1A expression and by increasing the stability of CCND1 protein
  • USP34-dependent deubiquitination is critical for root morphogenesis by stabilizing NFIC
  • cell & other
    REGULATION
    Other its expression might be regulated through epithelial-mesenchymal interaction
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in 69p100 of acute myeloid leukemia (AML) patients
    Susceptibility to uterine endometrial cancer (HEC)
    Variant & Polymorphism other
  • HEC patients at advanced stages tended to possess T/T alleles more frequently than healthy women
  • Candidate gene
    Marker
  • could be a marker gene for root odontoblasts differentiation initiation
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    is a potential therapeutic target in AML
    obesity  
    is a target for new therapies to control metabolic disorders like obesity
    osteoarticularboneostéoporosis
    is a target for new therapies to control metabolic disorders like osteoporosis
    osteoarticularboneostéoporosis
    regulation of NFIC expression in BMSCs could be a novel therapeutic approach for treating age-related osteoporosis
    ANIMAL & CELL MODELS
  • Nfic deficient mice exhibit short and abnormal molar roots and severely deformed incisors