basic FUNCTION
| recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2 |
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involved in stimulating the initiation of adenovirus DNA replication and the activation of transcription driven by RNA polymerase II |
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NFIC acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in bone marrow stromal cells (BMSCs) |
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implicated in the regulation of tooth root development, where it may be anticipated to impact on the behavior of stem cells from the apical papilla (SCAPs) and root odontoblast activity |
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upregulation of NFIC activity in SCAPs may promote osteo/odontoblastic differentiation of SCAPs |
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plays critical roles in the regulation of tooth development by influencing the biological behaviors of stem cells in the dental germ |
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upregulation of NFIC may promote the proliferation and osteogenic/cementogenic differentiation of dental follicle cells (DFCs) |
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is an important transcription factor in myeloid differentiation as well as AML cell survival |