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FLASH GENE
Symbol NFIC contributors: mct - updated : 10-01-2024
HGNC name nuclear factor I/C (CCAAT-binding transcription factor)
HGNC id 7786
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Digestivemouthtooth    Homo sapiens
Endocrinepancreas   moderately
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveameloblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one DWA/MH1 domain
  • a CTF/NF-i DNA-binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Nfic
    Homologene
    FAMILY CTF/NFI family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2
  • involved in stimulating the initiation of adenovirus DNA replication and the activation of transcription driven by RNA polymerase II
  • NFIC acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in bone marrow stromal cells (BMSCs)
  • implicated in the regulation of tooth root development, where it may be anticipated to impact on the behavior of stem cells from the apical papilla (SCAPs) and root odontoblast activity
  • upregulation of NFIC activity in SCAPs may promote osteo/odontoblastic differentiation of SCAPs
  • plays critical roles in the regulation of tooth development by influencing the biological behaviors of stem cells in the dental germ
  • upregulation of NFIC may promote the proliferation and osteogenic/cementogenic differentiation of dental follicle cells (DFCs)
  • is an important transcription factor in myeloid differentiation as well as AML cell survival
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RUNX2-NFIC-SP7 pathway is one of the key factors that regulate ameloblast differentiation
  • a component
  • INTERACTION
    DNA binds DNA as a homodimer
    RNA
    small molecule
    protein
  • NF1C is a candidate to regulate AHR transcription in a polymorphism-dependent manner
  • NFIC directly binds to the promoter of low-density lipoprotein receptor-related protein 5 (LRP5) and thereafter transactivates the promoter
  • NFIC may contribute to postnatal chondrocyte proliferation by inhibiting CDKN1A expression and by increasing the stability of CCND1 protein
  • USP34-dependent deubiquitination is critical for root morphogenesis by stabilizing NFIC
  • cell & other
    REGULATION
    Other its expression might be regulated through epithelial-mesenchymal interaction
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in 69p100 of acute myeloid leukemia (AML) patients
    Susceptibility to uterine endometrial cancer (HEC)
    Variant & Polymorphism other
  • HEC patients at advanced stages tended to possess T/T alleles more frequently than healthy women
  • Candidate gene
    Marker
  • could be a marker gene for root odontoblasts differentiation initiation
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    is a potential therapeutic target in AML
    obesity  
    is a target for new therapies to control metabolic disorders like obesity
    osteoarticularboneostéoporosis
    is a target for new therapies to control metabolic disorders like osteoporosis
    osteoarticularboneostéoporosis
    regulation of NFIC expression in BMSCs could be a novel therapeutic approach for treating age-related osteoporosis
    ANIMAL & CELL MODELS
  • Nfic deficient mice exhibit short and abnormal molar roots and severely deformed incisors