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FLASH GENE

Symbol

NFIC

contributors: - updated : 24-05-2006

HGNC name	nuclear factor I/C (CCAAT-binding transcription factor)
HGNC id	7786

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 3.359.615 - 3.463.602
Synonym name	CCAAT-binding transcription factor
Synonym symbol(s)	EVI158, CTF, NFI, CTF5

DNA

TYPE	functioning gene
STRUCTURE	97.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 2185 - 428 - Zhao V2 - - 2401 - 499 - Zhao

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Endocrine pancreas       moderately Nervous brain       moderately Reproductive male system prostate     moderately Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one DWA/MH1 domain
	a CTF/NF-i DNA-binding domain

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Nfic

Homologene

FAMILY

CTF/NFI family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2
	involved in stimulating the initiation of adenovirus DNA replication and the activation of transcription driven by RNA polymerase II

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binds DNA as a homodimer

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS