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FLASH GENE
Symbol NFIC contributors: - updated : 24-05-2006
HGNC name nuclear factor I/C (CCAAT-binding transcription factor)
HGNC id 7786
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one DWA/MH1 domain
  • a CTF/NF-i DNA-binding domain
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Nfic
    Homologene
    FAMILY CTF/NFI family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • recognizes and binds the palindromic sequence 5'- ttggcnnnnngccaa-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2
  • involved in stimulating the initiation of adenovirus DNA replication and the activation of transcription driven by RNA polymerase II
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds DNA as a homodimer
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS