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FLASH GENE

Symbol

MKI67

contributors: mct - updated : 16-02-2022

HGNC name	antigen identified by monoclonal antibody Ki-67
HGNC id	7107

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q26.2      Physical location : 129.894.926 - 129.924.468
Synonym name	proliferation-related Ki-67 antigen
	protein phosphatase 1, regulatory subunit 105
Synonym symbol(s)	RP11-380J17.2, KIA, KI67, MIB-, MIB-1, PPP1R105

DNA

TYPE	functioning gene
STRUCTURE	29.76 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002417 15 - 12716 NP_002408 358 3256 - 2004 15048881 MKI67 NM_001145966 14 - 11636 NP_001139438 319 2896 - 2004 15048881

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage
cell lines	proliferating cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

forkhead associated (FHA) domain

HOMOLOGY

interspecies

homolog to murine Mki67

Homologene

FAMILY

CATEGORY

DNA associated , antigen , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies
	intracellular,nucleus,chromatin/chromosome,centromere
	intracellular,nucleus,nucleolus

basic FUNCTION	required for maintening cell proliferation (cell-cycle associated nuclear non histone protein)
	low rather than high MKI67 protein expression is of prognostic importance in diffuse large B-cell lymphoma
	key marker associated with aggressively proliferating cancer cells and poor prognosis
	prevents chromosomes from collapsing into a single chromatin mass after nuclear envelope disassembly, thus enabling independent chromosome motility and efficient interactions with the mitotic spindle
	acts as a biological surfactant to disperse mitotic chromosomes
	MKI67, GNL2, and MDN1 play an important role in organizing the RNAmetasome network

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	control of cell proliferation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	KNSL7 (for the progression of mitosis)
	TP53 tumor suppressor indirectly downregulates transcription of the MKI67 gene

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in esophageal carcinoma (mild overexpression in moderate dysplasia) and breast carcinoma tumoral     --over   positive correlation was shown for its overexpression and tumor stage and lymph node metastasis, in clear cell renal cell carcinomas tumoral     --over   of KIT, TP53, and MKI67 reflects tumor grade and predicts survival in neuroendocrine carcinomas, but fail as prognostic markers in the subset of small cell lung cancer patients tumoral     --over   strongly associated with increased tumor thickness, presence of ulceration and tumor necrosis in melanoma ( tumoral     --over   endothelial proliferation assessed on MKI67 combined with the lack of CD105 expression is often associated with invasive cervical carcinoma ( tumoral     --low   significant association between MKI67 and survival was shown regardless of primary tumor proliferation in advanced breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	stronger and more robust prognostic marker than mitotic count in nodular melanoma (
	combined use of KRAS status and MKI67 expression level could be an excellent prognostic marker to predict the post-operative recurrence of stage I ADC (stage I lung adenocarcinomas)
Therapy target
	System Type Disorder Pubmed cancer     molecular target for therapy in cancer

ANIMAL & CELL MODELS