Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MKI67 contributors: mct - updated : 30-09-2011
HGNC name antigen identified by monoclonal antibody Ki-67
HGNC id 7107
DNA
TYPE functioning gene
STRUCTURE 29.54 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ZRANB1 10q26.13 zinc finger, RAN-binding domain containing 1 CTBP2 21q21.3 C-terminal binding protein 2 MRPS21P6 10q26 mitochondrial ribosomal protein S21 pseudogene 6 LOC387718 10 hypothetical gene supported by AK131010; BC062717 LOC387719 10 LOC387719 EDRF1 10q26.2 erythroid differentiation-related factor 1 MMP21 10q26.3 matrix metalloproteinase 21 UROS 10q25.2-q26.3 uroporphyrinogen III synthase (congenital erythropoietic porphyria) BCCIP 10q26.1 BRCA2 and CDKN1A interacting protein DDX32 10q26.3 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32 FANK1 10q26.2 fibronectin type 3 and ankyrin repeat domains 1 ADAM12 10q26.3 a disintegrin and metalloproteinase domain 12 (meltrin alpha) FLJ32938 10q26.2 hypothetical protein FLJ32938 DOCK1 10q26.13-q26.3 dedicator of cyto-kinesis 1 LOC387720 10 hypothetical gene supported by AK127642 LOC338623 10q26.2 similar to hypothetical protein B130055A05 MGC32871 10q26.3 hypothetical protein MGC32871 PTPRE 10q26 protein tyrosine phosphatase, receptor type, E MKI67 10q25-qter antigen identified by monoclonal antibody Ki-67 LOC387721 10 similar to bA442O18.2 (novel protein) MGMT 10q26 O-6-methylguanine-DNA methyltransferase LOC387722 10 LOC387722 FLJ11370 10q26.3 hypothetical protein FLJ11370 DKFZp667B0210 10q26.3 hypothetical protein DKFZp667B0210 LOC387723 10 LOC387723 TXNL2 6p25.3 thioredoxin-like 2 TCERG1L 10q26.3 transcription elongation regulator 1-like
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 12507 358 3256 - 2004 15048881
MKI67
14 - 11427 319 2896 - 2004 15048881
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines proliferating cells
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase, G1, S, G2, M
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
forkhead associated (FHA) domain
HOMOLOGY
interspecies homolog to murine Mki67
Homologene
FAMILY
CATEGORY DNA associated , antigen , protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,chromatin/chromosome,centromere
intracellular,nucleus,nucleolus
basic FUNCTION
  • required for maintening cell proliferation (cell-cycle associated nuclear non histone protein)
  • low rather than high MKI67 protein expression is of prognostic importance in diffuse large B-cell lymphoma
  • key marker associated with aggressively proliferating cancer cells and poor prognosis
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text control of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein KNSL7 (for the progression of mitosis)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal carcinoma (mild overexpression in moderate dysplasia) and breast carcinoma
    tumoral     --over  
    positive correlation was shown for its overexpression and tumor stage and lymph node metastasis, in clear cell renal cell carcinomas
    tumoral     --over  
    of KIT, TP53, and MKI67 reflects tumor grade and predicts survival in neuroendocrine carcinomas, but fail as prognostic markers in the subset of small cell lung cancer patients
    tumoral     --over  
    strongly associated with increased tumor thickness, presence of ulceration and tumor necrosis in melanoma (
    tumoral     --over  
    endothelial proliferation assessed on MKI67 combined with the lack of CD105 expression is often associated with invasive cervical carcinoma (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • stronger and more robust prognostic marker than mitotic count in nodular melanoma (
  • combined use of KRAS status and MKI67 expression level could be an excellent prognostic marker to predict the post-operative recurrence of stage I ADC (stage I lung adenocarcinomas)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    molecular target for therapy in cancer
    ANIMAL & CELL MODELS