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FLASH GENE
Symbol MKI67 contributors: mct - updated : 30-09-2011
HGNC name antigen identified by monoclonal antibody Ki-67
HGNC id 7107
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in esophageal carcinoma (mild overexpression in moderate dysplasia) and breast carcinoma
tumoral     --over  
positive correlation was shown for its overexpression and tumor stage and lymph node metastasis, in clear cell renal cell carcinomas
tumoral     --over  
of KIT, TP53, and MKI67 reflects tumor grade and predicts survival in neuroendocrine carcinomas, but fail as prognostic markers in the subset of small cell lung cancer patients
tumoral     --over  
strongly associated with increased tumor thickness, presence of ulceration and tumor necrosis in melanoma (
tumoral     --over  
endothelial proliferation assessed on MKI67 combined with the lack of CD105 expression is often associated with invasive cervical carcinoma (
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • stronger and more robust prognostic marker than mitotic count in nodular melanoma (
  • combined use of KRAS status and MKI67 expression level could be an excellent prognostic marker to predict the post-operative recurrence of stage I ADC (stage I lung adenocarcinomas)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    molecular target for therapy in cancer
    ANIMAL & CELL MODELS