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FLASH GENE
Symbol MKI67 contributors: mct - updated : 30-09-2011
HGNC name antigen identified by monoclonal antibody Ki-67
HGNC id 7107
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 12507 358 3256 - 2004 15048881
MKI67
14 - 11427 319 2896 - 2004 15048881
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines proliferating cells
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase, G1, S, G2, M
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
forkhead associated (FHA) domain
HOMOLOGY
interspecies homolog to murine Mki67
Homologene
FAMILY
CATEGORY DNA associated , antigen , protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,chromatin/chromosome,centromere
intracellular,nucleus,nucleolus
basic FUNCTION
  • required for maintening cell proliferation (cell-cycle associated nuclear non histone protein)
  • low rather than high MKI67 protein expression is of prognostic importance in diffuse large B-cell lymphoma
  • key marker associated with aggressively proliferating cancer cells and poor prognosis
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text control of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein KNSL7 (for the progression of mitosis)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal carcinoma (mild overexpression in moderate dysplasia) and breast carcinoma
    tumoral     --over  
    positive correlation was shown for its overexpression and tumor stage and lymph node metastasis, in clear cell renal cell carcinomas
    tumoral     --over  
    of KIT, TP53, and MKI67 reflects tumor grade and predicts survival in neuroendocrine carcinomas, but fail as prognostic markers in the subset of small cell lung cancer patients
    tumoral     --over  
    strongly associated with increased tumor thickness, presence of ulceration and tumor necrosis in melanoma (
    tumoral     --over  
    endothelial proliferation assessed on MKI67 combined with the lack of CD105 expression is often associated with invasive cervical carcinoma (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • stronger and more robust prognostic marker than mitotic count in nodular melanoma (
  • combined use of KRAS status and MKI67 expression level could be an excellent prognostic marker to predict the post-operative recurrence of stage I ADC (stage I lung adenocarcinomas)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    molecular target for therapy in cancer
    ANIMAL & CELL MODELS