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FLASH GENE
Symbol MAT1A contributors: npt - updated : 23-09-2004
HGNC name methionine adenosyltransferase I, alpha
HGNC id 6903
Corresponding disease
MAT1A methionine adenosyltransferase deficiency
Location 10q23.1      Physical location : 82.031.576 - 82.049.434
Synonym name
  • S-adenosylmethionine synthetase 1
  • methionine adenosyltransferase I/III
  • AdoMet synthase 1
  • Synonym symbol(s) MAT, SAMS, MATA1, SAMS1, METL, MAT-I/III, AMS1
    EC.number 2.5.1.6
    DNA
    TYPE functioning gene
    STRUCTURE 17.86 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RAI17 10q23.2 retinoic acid induced 17 PPIF 10q22.3 peptidylprolyl isomerase F (cyclophilin F) FLJ90798 10q23.1 hypothetical protein FLJ90798 LOC338586 10q23.1 similar to XRnf12C LOC143244 10q23.1 similar to eukaryotic initiation factor 5A isoform I variant A LOC389981 10 similar to mannose-binding protein A LOC389982 10 similar to mKIAA1553 protein LOC387692 10 similar to KIAA2020 protein EIF5AP1 10q23.3 eukaryotic translation initiation factor 5A pseudogene 1 LOC389983 10 similar to Gene with similarity to rat kidney-specific (KS) gene SFTPA2 10q22-q23 surfactant, pulmonary-associated protein A2 SFTPA1 10q22.3 surfactant, pulmonary-associated protein A1 LOC389984 10 similar to KIAA1553 protein LOC389985 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC389986 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC340736 10q23.1 similar to Cathepsin L preproprotein LOC283004 10q23.1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) LOC387693 10 similar to BMS1-like, ribosome assembly protein; ribosome biogenesis protein BMS1 homolog; cDNA sequence BC030906; EST AA408648 SFTPD 10q22.3 surfactant, pulmonary-associated protein D LOC389987 10 similar to nuclear DNA-binding protein; small unique nuclear receptor corepressor; C1D DNA-binding protein LOC389988 10 similar to nuclear DNA-binding protein; small unique nuclear receptor corepressor; C1D DNA-binding protein LOC389989 10 hypothetical gene supported by BC016284; NM_173177 FLJ13263 10q23.1 hypothetical protein FLJ13263 PLAC9 10q23.2 placenta-specific 9 ANXA11 10q22.3 annexin A11 LOC143243 10q23.1 similar to eukaryotic initiation factor 5A isoform I variant A MAT1A 10q22 methionine adenosyltransferase I, alpha LOC143241 10q23.1 hypothetical protein BC019250 MGC16186 10q23.1 hypothetical protein MGC16186 MGC4248 10q23.1 hypothetical protein MGC4248 DC-TM4F2 10q23.1 tetraspanin similar to TM4SF9 LOC387694 10 similar to hypothetical protein D030001E08 LOC389990 10 similar to Replication protein A 32 kDa subunit (RP-A) (RF-A) (Replication factor-A protein 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3419 - 395 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    Cardiovascularheart   lowly
    Digestiveliver   specific
    Nervousbrain   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Mat1a
    Homologene
    FAMILY
  • AdoMet synthetase family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine (AdoMet) which is the source of methyl groups for most biological methylations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
  • complex of MATI (homotetramer of alpha 1 submit encoded by MAT1A)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MAT1A
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS