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FLASH GENE
Symbol MAT1A contributors: npt - updated : 23-09-2004
HGNC name methionine adenosyltransferase I, alpha
HGNC id 6903
Corresponding disease
MAT1A methionine adenosyltransferase deficiency
Location 10q23.1      Physical location : 82.031.576 - 82.049.434
Synonym name
  • S-adenosylmethionine synthetase 1
  • methionine adenosyltransferase I/III
  • AdoMet synthase 1
    • Synonym symbol(s) MAT, SAMS, MATA1, SAMS1, METL, MAT-I/III, AMS1
    EC.number 2.5.1.6
    DNA
    TYPE functioning gene
    STRUCTURE 17.86 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3419 - 395 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    Cardiovascularheart   lowly
    Digestiveliver   specific
    Nervousbrain   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Mat1a
    Homologene
    FAMILY
  • AdoMet synthetase family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine (AdoMet) which is the source of methyl groups for most biological methylations
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
  • complex of MATI (homotetramer of alpha 1 submit encoded by MAT1A)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MAT1A
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS