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FLASH GENE
Symbol MAT1A contributors: npt - updated : 23-09-2004
HGNC name methionine adenosyltransferase I, alpha
HGNC id 6903
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
Cardiovascularheart   lowly
Digestiveliver   specific
Nervousbrain   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to murine Mat1a
Homologene
FAMILY
  • AdoMet synthetase family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine (AdoMet) which is the source of methyl groups for most biological methylations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
  • complex of MATI (homotetramer of alpha 1 submit encoded by MAT1A)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MAT1A
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS