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FLASH GENE

Symbol

MAT1A

contributors: npt - updated : 23-09-2004

HGNC name	methionine adenosyltransferase I, alpha
HGNC id	6903

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.86 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000429 9 - 3419 NP_000420 - 395 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       lowly Cardiovascular heart       lowly Digestive liver       specific Nervous brain       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

interspecies

homolog to murine Mat1a

Homologene

FAMILY

AdoMet synthetase family

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION

basic FUNCTION

catalyzing a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine (AdoMet) which is the source of methyl groups for most biological methylations

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

a component

complex of MATI (homotetramer of alpha 1 submit encoded by MAT1A)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MAT1A

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS