Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | KLK1 | contributors: mct - updated : 19-05-2009 |
HGNC name | kallikrein 1 |
HGNC id | 6357 |
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Location | 19q13.33 Physical location : 51.322.403 - 51.327.043 |
Synonym name | |
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Synonym symbol(s) | KLKR, KLK6, hK1 |
EC.number | 3.4.21.35 |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | component of a cluster |
text | tightly clustered multigene family on chromosome 19q13.4 |
STRUCTURE | 4.64 kb 5 Exon(s) |
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10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
Binding site enhancer | |
motif | repetitive sequence other |
text structure | |
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MAPPING | cloned | Y | linked | Y | status | confirmed |
Map | cen - APOC2 APOC2 - CKM - ERCC1 - DM1 - D19S321 - GYS1 - D19S320 - [KLK1 - KLK3 - KLK2 ] - D19S50 - D19S22 - qter |
Physical map
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regionally located | clustered with kallikrein gene family |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
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HOMOLOGY |
Homologene |
FAMILY | |
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CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | extracellular |
| intracellular |
intracellular,cytoplasm |
basic FUNCTION | |
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CELLULAR PROCESS | protein, degradation |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component | ![]() |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility | to hypertension and/or hypertension asociated with end- stage renal disease |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |