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FLASH GENE
Symbol KLK1 contributors: mct - updated : 19-05-2009
HGNC name kallikrein 1
HGNC id 6357
Location 19q13.33      Physical location : 51.322.403 - 51.327.043
Synonym name
  • glandular kallikrein, renal
  • kallikrein 1, renal/pancreas/salivary
  • kallikrein serine protease 1
  • kidney/pancreas/salivary gland kallikrein
  • Synonym symbol(s) KLKR, KLK6, hK1
    EC.number 3.4.21.35
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 4.64 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer
    motif repetitive sequence   other
    text structure
  • poly- g length polymorphism
  • a GATA3 binding site in -954/-855 of the promoter
  • MAPPING cloned Y linked Y status confirmed
    Map cen - APOC2 APOC2 - CKM - ERCC1 - DM1 - D19S321 - GYS1 - D19S320 - [KLK1 - KLK3 - KLK2 ] - D19S50 - D19S22 - qter
    Physical map
    LOC284361 19q13.33-q13.41 hypothetical protein LOC284361 SBBI54 19q13.41 hypothetical transmembrane protein SBBI54 LOC284363 19q13.41 similar to RIKEN cDNA 0610012D14 DKFZp761A179 SYT3 19q13.4 synaptotagmin III LOC342918 19q13.41 hypothetical LOC342918 SHANK1 19q13.3 SH3 and multiple ankyrin repeat domains 1 SCGF 19q13.3 stem cell growth factor; lymphocyte secreted C-type lectin GPR32P 19q13.3 G protein-coupled receptor 32, pseudogene GPR32 19q13.3 G protein-coupled receptor 32 ACPT 19q13.4 acid phosphatase, testicular MGC13170 19q13.41 multidrug resistance-related protein MGC45922 19q13.41 hypothetical gene MGC45922 KLK1 19q13.4 kallikrein 1, renal/pancreas/salivary KLK15 19q13.4 kallikrein 1, renal/pancreas/salivary KLK3 19q13.3 kallikrein 3, (prostate specific antigen) KLK2 19q13.4 kallikrein 2, prostatic KLK4 19q13.3-q13.4 kallikrein 4 (prostase, enamel matrix, prostate) LOC390956 19 similar to peptidyl-Pro cis trans isomerase KLK5 19q13.3-q13.4 kallikrein 5 KLK6 19q13.3 kallikrein 6 (neurosin, zyme) KLK7 19q13.41 kallikrein 7 (chymotryptic, stratum corneum) KLK8 19q13.3 kallikrein 8 (neuropsin/ovasin) KLK9 19q13.3-q13.4 kallikrein 9 KLK10 19q13.3 kallikrein 10 KLK11 19q13.3-q13.4 kallikrein 11 KLK12 19q13.3-q13.4 kallikrein 12 KLK13 19q13.2-q13.4 kallikrein 13 KLK14 19q13.3-q13.4 kallikrein 14 LOC90353 19q13.41 LOC90353 SIGLEC9 19q13.4 sialic acid binding Ig-like lectin 9 SIGLEC7 19q13.3 sialic acid binding Ig-like lectin 7
    regionally located clustered with kallikrein gene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 874 28.7 262 - 1991 1783409
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
     vessel     Homo sapiens
    Digestivesalivary gland   highly
    Endocrinepancreas   highly
    Lymphoid/Immunetonsils   highly
    Skin/Tegumentskin   highly
    Urinarykidneytubule  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a peptidase S1 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serine protease, releasing the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen
  • as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI
  • critical role in arterial function
  • is also involved in the control of ionic transport in the renal tubule, an action that may not be kinin-mediated
  • kinin-forming serine protease synthesized in many organs including arteries and kidney
  • tissue KLK1 is essential for invasive capacity of circulating proangiogenic cells
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of KLK proteolytic cascade with KLK11 and KLK3, activated by KLK14
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    decreased in renal clear cell carcinoma
    Susceptibility to hypertension and/or hypertension asociated with end- stage renal disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS