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FLASH GENE
Symbol KLK2 contributors: mct/npt - updated : 10-11-2009
HGNC name kallikrein-related peptidase 2
HGNC id 6363
Location 19q13.33      Physical location : 51.376.688 - 51.383.822
Synonym name
  • kallikrein 2, prostatic
  • glandular kallikrein-1
  • tissue kallikrein-2
  • EC.number 3.4.21.35
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text tightly clustered multigene family on chromosome 19q13.4
    STRUCTURE 7.13 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure androgen response elements in the promoter and enhancer of KLK2 , interacting with the androgen receptor (Lawrence 2010)
    MAPPING cloned Y linked N status confirmed
    Map see KLK1
    Physical map
    LOC284361 19q13.33-q13.41 hypothetical protein LOC284361 SBBI54 19q13.41 hypothetical transmembrane protein SBBI54 LOC284363 19q13.41 similar to RIKEN cDNA 0610012D14 DKFZp761A179 SYT3 19q13.4 synaptotagmin III LOC342918 19q13.41 hypothetical LOC342918 SHANK1 19q13.3 SH3 and multiple ankyrin repeat domains 1 SCGF 19q13.3 stem cell growth factor; lymphocyte secreted C-type lectin GPR32P 19q13.3 G protein-coupled receptor 32, pseudogene GPR32 19q13.3 G protein-coupled receptor 32 ACPT 19q13.4 acid phosphatase, testicular MGC13170 19q13.41 multidrug resistance-related protein MGC45922 19q13.41 hypothetical gene MGC45922 KLK1 19q13.4 kallikrein 1, renal/pancreas/salivary KLK15 19q13.4 kallikrein 1, renal/pancreas/salivary KLK3 19q13.3 kallikrein 3, (prostate specific antigen) KLK2 19q13.4 kallikrein 2, prostatic KLK4 19q13.3-q13.4 kallikrein 4 (prostase, enamel matrix, prostate) LOC390956 19 similar to peptidyl-Pro cis trans isomerase KLK5 19q13.3-q13.4 kallikrein 5 KLK6 19q13.3 kallikrein 6 (neurosin, zyme) KLK7 19q13.41 kallikrein 7 (chymotryptic, stratum corneum) KLK8 19q13.3 kallikrein 8 (neuropsin/ovasin) KLK9 19q13.3-q13.4 kallikrein 9 KLK10 19q13.3 kallikrein 10 KLK11 19q13.3-q13.4 kallikrein 11 KLK12 19q13.3-q13.4 kallikrein 12 KLK13 19q13.2-q13.4 kallikrein 13 KLK14 19q13.3-q13.4 kallikrein 14 LOC90353 19q13.41 LOC90353 SIGLEC9 19q13.4 sialic acid binding Ig-like lectin 9 SIGLEC7 19q13.3 sialic acid binding Ig-like lectin 7
    regionally located clustered with kallikrein gene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2892 - 223 - Qin (1991)
    5 - 2855 - 261 - Qin (1991)
    - - - - - may be expressed in the secretory epithelial cells of the prostate David (2002)
  • also called K-LM
  • hK2-linked molecule (K-LM), sharing only the signal peptide with the original protein product of the respective gene
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
     male systemprostate    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • serine protease with three alternatively spliced isoforms
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • kallikrein family
  • peptidase S1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a role in prostate cancer susceptibility and this role may be realized at least in part by the induction of increases in its production (Nam 2006)
  • highly prostate-specific serine protease, which is mainly excreted into the seminal fluid (Pakkala 2007)
  • may mediate tumor growth and invasion by participating in proteolytic cascades (Koistinen 2008)
  • direct transcriptional target (Lawrence 2010)
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with protease inhibitor 6 in prostate cancer tissue
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    Fusion of KLK2 to ETV4 in prostate cancer results in the generation of an additional ETV4 exon, denoted exon 4a (Hermans 2008)
    tumoral     --over  
    in prostate cancer (Koistinen 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • produced and secreted in the prostate and have important applications in the diagnosis of prostate cancer (David 2002)
  • potential target for tumor imaging and treatment in prostate cancer cells (Koistinen 2008)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS