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FLASH GENE

Symbol

APOC2

contributors: - updated : 05-04-2007

HGNC name	apolipoprotein C-II
HGNC id	609

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	APOC2 hyperlipoproteinemia, type IB (CII deficiency)
Location	19q13.2      Physical location : 45.449.242 - 45.452.817
Synonym symbol(s)	MGC75082, APC2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	3.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine neuroendocrine pituitary     moderately Lymphoid/Immune spleen       highly Skin/Tegument skin       lowly Urinary kidney       moderately Visual eye retina     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining retinal pigment epithelium (RPE)

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

physiological period

perinatal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to dog APOC2 (65.00 pc)
	homolog to rattus Apoc2 (65.98 pc)
	homolog to murine Apoc2 (61.86 pc)

Homologene

FAMILY

apolipoprotein C2 family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

activator of several tri-acylglycerollipases

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

APOC2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS