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FLASH GENE
Symbol ITGA4 contributors: mct - updated : 24-10-2009
HGNC name integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
HGNC id 6140
Location 2q31.3      Physical location : 182.321.618 - 182.402.466
Synonym name
  • cell differentiation antigen CD49D, identified by antibodies B5G10,HP2/1,HP1/3
  • 269C wild type
  • antigen CD49D, alpha-4 subunit of VLA-4 receptor
  • very late antigen 4
  • integrin alpha-IV
  • Synonym symbol(s) CD49D, VLA4A, IA4, MGC90518, VLA4
    DNA
    TYPE functioning gene
    STRUCTURE 80.85 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC391465 2 similar to STIP1 homology and U-Box containing protein 1; serologically defined colon cancer antigen 7; carboxy terminus of Hsp70p-interacting protein; heat shock protein A binding protein 2 (c-terminal) LOC150739 2q31.2 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 hnRNPA3 2q31.2 heterogeneous nuclear ribonucleoprotein A3 NFE2L2 2q31 nuclear factor (erythroid-derived 2)-like 2 DKFZp451M2119 2q31.2-q31.3 hypothetical protein DKFZp451M2119 AGPS 2q33 alkylglycerone phosphate synthase FLJ30990 2q31.3 hypothetical protein FLJ30990 FLJ13946 2q31.3 hypothetical protein FLJ13946 PDE11A 2q31 phosphodiesterase 11A HCP9 2q31.2 cytochrome c, somatic pseudogene DRB1 2q31.3 developmentally regulated RNA-binding protein 1 OSBPL6 2q31-q32.1 oxysterol binding protein-like 6 PRKRA 2q31.2 protein kinase, interferon-inducible double stranded RNA dependent activator NUDCP2 2q31 nuclear distribution gene C homolog (A. nidulans) pseudogene 2 FKBP7 2q31.2 FK506 binding protein 7 PLEKHA3 2q31.2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 TTN 2q24.3-q31 titin FLJ39502 2q31.3 hypothetical protein FLJ39502 DKFZp434O0515 FLJ25270 LOC389065 2 similar to RIKEN cDNA B830010L13 gene LOC391466 2 similar to dim1 KIAA1604 2q32.1 KIAA1604 protein UBE2E3 2q32.1 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) ITGA4 2q31-q32 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) LOC151274 2q32.1 similar to Ceramide kinase (Acylsphingosine kinase) (mCERK) NEUROD1 2q32 neurogenic differentiation 1 SSFA2 2q32.1 sperm specific antigen 2 LOC344318 2q32.1 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC151242 2q32.1 protein phosphatase 1 regulatory subunit 1A PDE1A 2q32 phosphodiesterase 1A, calmodulin-dependent ERdj5 2q32.1 ER-resident protein ERdj5 FRZB 2q24-q31 frizzled-related protein NCKAP1 2q32 NCK-associated protein 1 LOC344320 2q32.1 similar to keratin 8, type II cytoskeletal - human DUSP19 2q32.1 dual specificity phosphatase 19 LOC129401 2q32.1 mitotic phosphoprotein 44 LOC129402 2q32.1 similar to lin-28 homolog; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1 LOC150503 2q32.1 similar to calcyclin binding protein LOC91752 2q32.1 similar to C630007C17Rik protein PRO2964 2q32.1 hypothetical protein PRO2964 LOC389066 2 LOC389066 LOC151273 2q32.1 similar to E74-like factor 2 (ets domain transcription factor); new Ets-related factor FLJ34780 2q32.1 hypothetical protein FLJ34780
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 6082 - 1032 - 2008 18348195
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal large extracellular domain consisting of a sevenfold repeated structure
  • putative cation-binding motif in the three of four C terminal repeats, cleaved into two fragments non covalently associated, domain connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • not only mediates the adhesion and transendothelial migration of leukocytes, but also provides costimulatory signals that contribute to the activation of T lymphocytes
  • playing a regulatory role on T lymphocyte-antigen presenting cell cognate immune interactions
  • distinct roles of ITGA6 and ITGA4 in homing of fetal liver hematopoietic stem and progenitor cells (Pubmed 17586725)
  • could be involved in a neuroimmune process thought to occur in autistic patients and, together with previous findings, offers a new perspective on the role of integrins in the etiology of autism
  • predominantly accumulates at the leading edge of migrating cells, rather than at focal adhesions
  • LPAR1 and ITGA4 regulate peripheral blood monocyte counts
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of VLA-4 receptor, VCAM1 receptors
  • dimerizing with ITGB1 or ITGB7 in fibronectin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AMICA1 (ITGA4 and AMICA1 functions are coordinately regulated, allowing AMICA1 to strengthen integrin-dependent adhesion of leukocytes to endothelial cells
  • ABI1 is a target of ITGA4 that positively regulates membrane protrusion by promoting actin polymerization at sites of integrin engagement
  • interaction between ITGA4 and BCAM proteins has been recently shown, suggesting that Lu/BCAM may have a role in leukocyte recruitments in inflamed tissues
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism other polymorphisms increasing the risk of multiple sclerosis
    Candidate gene
  • relevance of protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
  • candidate gene for autism
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for inflammatory immune disorders
    cancermetastases 
    development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for the treatment of metastatic tumors
    ANIMAL & CELL MODELS