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FLASH GENE

Symbol

ITGA4

contributors: mct - updated : 24-10-2009

HGNC name	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
HGNC id	6140

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000885 28 - 6082 NP_000876 - 1032 - 2008 18348195

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   thymus       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal large extracellular domain consisting of a sevenfold repeated structure
	putative cation-binding motif in the three of four C terminal repeats, cleaved into two fragments non covalently associated, domain connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

integrin alpha chain family

CATEGORY

adhesion , antigen , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
	not only mediates the adhesion and transendothelial migration of leukocytes, but also provides costimulatory signals that contribute to the activation of T lymphocytes
	playing a regulatory role on T lymphocyte-antigen presenting cell cognate immune interactions
	distinct roles of ITGA6 and ITGA4 in homing of fetal liver hematopoietic stem and progenitor cells (Pubmed 17586725)
	could be involved in a neuroimmune process thought to occur in autistic patients and, together with previous findings, offers a new perspective on the role of integrins in the etiology of autism
	predominantly accumulates at the leading edge of migrating cells, rather than at focal adhesions
	LPAR1 and ITGA4 regulate peripheral blood monocyte counts

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	constituent of VLA-4 receptor, VCAM1 receptors
	dimerizing with ITGB1 or ITGB7 in fibronectin

INTERACTION

DNA

RNA

small molecule

protein	interacting with AMICA1 (ITGA4 and AMICA1 functions are coordinately regulated, allowing AMICA1 to strengthen integrin-dependent adhesion of leukocytes to endothelial cells
	ABI1 is a target of ITGA4 that positively regulates membrane protrusion by promoting actin polymerization at sites of integrin engagement
	interaction between ITGA4 and BCAM proteins has been recently shown, suggesting that Lu/BCAM may have a role in leukocyte recruitments in inflamed tissues

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to multiple sclerosis

Variant & Polymorphism other	polymorphisms increasing the risk of multiple sclerosis

Candidate gene	relevance of protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
	candidate gene for autism
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for inflammatory immune disorders cancer metastases   development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for the treatment of metastatic tumors

ANIMAL & CELL MODELS