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FLASH GENE
Symbol ITGA4 contributors: mct - updated : 24-10-2009
HGNC name integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
HGNC id 6140
DNA
TYPE functioning gene
STRUCTURE 80.85 kb     28 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 6082 - 1032 - 2008 18348195
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 thymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal large extracellular domain consisting of a sevenfold repeated structure
  • putative cation-binding motif in the three of four C terminal repeats, cleaved into two fragments non covalently associated, domain connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • not only mediates the adhesion and transendothelial migration of leukocytes, but also provides costimulatory signals that contribute to the activation of T lymphocytes
  • playing a regulatory role on T lymphocyte-antigen presenting cell cognate immune interactions
  • distinct roles of ITGA6 and ITGA4 in homing of fetal liver hematopoietic stem and progenitor cells (Pubmed 17586725)
  • could be involved in a neuroimmune process thought to occur in autistic patients and, together with previous findings, offers a new perspective on the role of integrins in the etiology of autism
  • predominantly accumulates at the leading edge of migrating cells, rather than at focal adhesions
  • LPAR1 and ITGA4 regulate peripheral blood monocyte counts
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of VLA-4 receptor, VCAM1 receptors
  • dimerizing with ITGB1 or ITGB7 in fibronectin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AMICA1 (ITGA4 and AMICA1 functions are coordinately regulated, allowing AMICA1 to strengthen integrin-dependent adhesion of leukocytes to endothelial cells
  • ABI1 is a target of ITGA4 that positively regulates membrane protrusion by promoting actin polymerization at sites of integrin engagement
  • interaction between ITGA4 and BCAM proteins has been recently shown, suggesting that Lu/BCAM may have a role in leukocyte recruitments in inflamed tissues
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis
    Variant & Polymorphism other polymorphisms increasing the risk of multiple sclerosis
    Candidate gene
  • relevance of protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
  • candidate gene for autism
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for inflammatory immune disorders
    cancermetastases 
    development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for the treatment of metastatic tumors
    ANIMAL & CELL MODELS