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FLASH GENE
Symbol ITGA4 contributors: mct - updated : 24-10-2009
HGNC name integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
HGNC id 6140
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility to multiple sclerosis
Variant & Polymorphism other polymorphisms increasing the risk of multiple sclerosis
Candidate gene
  • relevance of protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
  • candidate gene for autism
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for inflammatory immune disorders
    cancermetastases 
    development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for the treatment of metastatic tumors
    ANIMAL & CELL MODELS