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FLASH GENE
Symbol ITGA2 contributors: mct - updated : 09-05-2007
HGNC name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
HGNC id 6137
Location 5q11.2      Physical location : 52.285.155 - 52.390.608
Synonym name platelet glycoprotein Ia; cell differentiation antigen CD49B, identified by antibodies CLB-thromb/4, Gil4
Synonym symbol(s) CD49B, VLA2A, VLAA2, BR, GPIA, VLA2
DNA
TYPE functioning gene
STRUCTURE 102.00 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC202319 5q11.2 similar to cyclophilin-LC; cyclophilin homolog overexpressed in liver cancer; chromosome 1 amplified sequence 2 FLJ21308 5q11.2 hypothetical protein FLJ21308 LOC153630 5q11.2 hypothetical LOC153630 LOC133569 5q11.2 similar to 40S ribosomal protein S10 ISL1 5q11.1 ISL1 transcription factor, LIM/homeodomain, (islet-1) PELO 5q11.2 pelota homolog (Drosophila) ITGA1 5p15-p11 integrin, alpha 1 ITGA2 5q23-q31 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) MOCS2 5q11 molybdenum cofactor synthesis 2 LOC391781 5 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC391782 5 similar to ribosomal protein S19; 40S ribosomal protein S19 FST 5p11.2 follistatin NDUFS4 5q11.1 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) ASSP9 5q11-q12 argininosuccinate synthetase pseudogene 9 FLJ20051 HSPB3 5q11.2 heat shock 27kDa protein 3 SNAG1 5q11.2 sorting nexin associated golgi protein 1 LOC389290 5 LOC389290 LOC391783 5 similar to membrane-spanning proteoglycan NG2 LOC391784 5 similar to CG12279-PA LOC153134 5q11.2 hypothetical LOC153134 ESM1 5q11.2 endothelial cell-specific molecule 1 GZMK 5q11-q12 granzyme K (serine protease, granzyme 3; tryptase II) GZMA 5q11-q12 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) FLJ37927 5q11.2 CDC20-like protein LOC345643 5q11.2 similar to geminin UNG2 5p15.2-p13.1 uracil-DNA glycosylase 2 DHX29 5q11.2 DEAH (Asp-Glu-Ala-His) box polypeptide 29
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestivemouth   moderately
 stomach   moderately
Endocrinepancreas   moderately
Lymphoid/Immunespleen   lowly
Nervousbrainforebraincerebral lobefrontallowly
Respiratorylung   lowly
 respiratory tracttrachea  highly
Urinarybladder   highly
 kidney   moderately
Visualeye   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connectiveadipose  lowly
Epithelialbarrier/liningepidermisstratum basalemoderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text embryonic tissue at a lowly level
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 29 amino acids signal peptide (2.9 kDa)
  • a N terminal large extracellular domain consisting of a sevenfold repeated structure with putative cation-binding motifs in the three of four C terminal repeats (FG-GAP) repeats.
  • and an I domain inserted between the second and third repeats ligand binding. This domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • one VWFA domain.
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor a 1152 amino acids mature peptide (126.4 kDa)
    HOMOLOGY
    interspecies homolog to chimpanzee ITGA2 (99.75 pc)
    homolog to rattus Itga2 (81.83 pc)
    homolog to murine Itga2 (82.60 pc)
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • playing a role in tumour development (FitzGerald 2009)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of VLA-2 receptor
  • dimerizing with ITGB1 in collagen, laminin receptors
  • INTERACTION
    DNA
    RNA
    small molecule
    protein collagen (control of collagen expression)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    deficiency of platelet receptor for collagen
    constitutional germinal mutation      
    fetal and neonatal alloimmune thrombocytopenia [alloantigène Br(a)]
    Susceptibility
  • to prostate cancer and other cancers
  • to coronary atherosclerosis
  • Variant & Polymorphism SNP
  • rs3212649 and rs1126643, significantly associated in both familial and sporadic prostate cancer (FitzGerald 2009)
  • rs3212556 associated with coronary atherosclerosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS