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FLASH GENE
Symbol ITGA2 contributors: mct - updated : 09-05-2007
HGNC name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
HGNC id 6137
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
deficiency of platelet receptor for collagen
constitutional germinal mutation      
fetal and neonatal alloimmune thrombocytopenia [alloantigène Br(a)]
Susceptibility
  • to prostate cancer and other cancers
  • to coronary atherosclerosis
  • Variant & Polymorphism SNP
  • rs3212649 and rs1126643, significantly associated in both familial and sporadic prostate cancer (FitzGerald 2009)
  • rs3212556 associated with coronary atherosclerosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS