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FLASH GENE
Symbol ITGA2 contributors: mct - updated : 09-05-2007
HGNC name integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
HGNC id 6137
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 29 amino acids signal peptide (2.9 kDa)
  • a N terminal large extracellular domain consisting of a sevenfold repeated structure with putative cation-binding motifs in the three of four C terminal repeats (FG-GAP) repeats.
  • and an I domain inserted between the second and third repeats ligand binding. This domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • one VWFA domain.
  • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor a 1152 amino acids mature peptide (126.4 kDa)
    HOMOLOGY
    interspecies homolog to chimpanzee ITGA2 (99.75 pc)
    homolog to rattus Itga2 (81.83 pc)
    homolog to murine Itga2 (82.60 pc)
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • playing a role in tumour development (FitzGerald 2009)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of VLA-2 receptor
  • dimerizing with ITGB1 in collagen, laminin receptors
  • INTERACTION
    DNA
    RNA
    small molecule
    protein collagen (control of collagen expression)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    deficiency of platelet receptor for collagen
    constitutional germinal mutation      
    fetal and neonatal alloimmune thrombocytopenia [alloantigène Br(a)]
    Susceptibility
  • to prostate cancer and other cancers
  • to coronary atherosclerosis
  • Variant & Polymorphism SNP
  • rs3212649 and rs1126643, significantly associated in both familial and sporadic prostate cancer (FitzGerald 2009)
  • rs3212556 associated with coronary atherosclerosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS