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FLASH GENE

Symbol

IL24

contributors: mct - updated : 14-12-2013

HGNC name	interleukin 24
HGNC id	11346

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q32.1      Physical location : 207.070.787 - 207.077.484
Synonym name	melanoma differentiation association protein 7, suppression of tumorigenicity 16
Synonym symbol(s)	IL10B, MDA7, ST16, L49A, FISP, MDA-7, C49A, Mob-5

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	6.85 kb     7 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	proximal promoter region (-157/+95 bp) that plays critical role in activating the IL24 gene in Th2 cells

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006850 7 splicing 1976 NP_006841 23 206 - 2011 21843952 variant 2 - splicing 1633 5 48 - 2011 21843952 lacking an internal segment compared to variant 1 the resulting shorter isoform (2) is identical to the C-terminal region of isoform 1 lacking exons 3 and 5 NM_001185157 6 - 1820 NP_001172086 - 154 - 2011 21843952 NM_001185158 5 - 1621 NP_001172087 - 63 - 2011 21843952 NM_001185156 7 - 1979 NP_001172085 - 207 - 2011 21843952

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Lymphoid/Immune lymph node       highly   spleen           thymus         Reproductive female system breast         male system prostate     moderately Respiratory lung       moderately

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Homo sapiens Lymphoid/Immune T cell Homo sapiens Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle

life cycle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP , ubiquitinated

HOMOLOGY

interspecies	homolog to rattus Il24
	ortholog to murine Il24

Homologene

FAMILY

cytokine family (IL10 family)

CATEGORY

tumor suppressor , signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	involved in growth control and terminal differentiation in cancer cells, negative regulator of melanoma progression
	functions potentially during an inflammatory response in the skin by inhibiting the proliferation and migration of keratinocytes
	specifically inhibits cancer cell growth through the induction of cell cycle arrest and apoptosis
	suppressed mRNA expression of vascular endothelial growth factor and platelet-derived growth factor and subsequently decreased the level of cell migration in response to H(2)O(2)
	suppress tumor progression in a variety of human cancers
	cytokine with potent antitumour and tumour-suppressive activity which functions through its receptor (IL22R)
	plays a profound role in suppressing tumour lymphangiogenesis, thereby, reducing the likelihood of cancer metastasis via the lymphatic route
	IL24 and IL19 are involved in host defence against bacteria and fungi, tissue remodelling and wound healing

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MAPK14 is a regulator of IL24 expression and determine interference with destabilization mediated by the 3prime UTR of IL24 mRNA as mode of action
	STAT6 and JUN proteins were found to physically cooperate with each other and upregulated IL24 gene transcription
	IL24 reduces VSMC calcification by inhibiting the WNT/CTNNB1 pathway
	SIGMAR1 is a key initial mediator of IL24 induction of cancer-specific killing

cell & other

REGULATION

Other

ubiquitinated and degraded by the 26S proteasome

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in primary melanoma in progression to invasive and metastatic stages tumoral     --low   in breast cancer, is associated with lymphatic metastases and a poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired   is a potential therapeutic agent in vascular smooth muscle cell (VSMC) calcification

ANIMAL & CELL MODELS