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FLASH GENE
Symbol IL24 contributors: mct - updated : 14-12-2013
HGNC name interleukin 24
HGNC id 11346
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 6.85 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • proximal promoter region (-157/+95 bp) that plays critical role in activating the IL24 gene in Th2 cells
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC391156 1 LOC391156 FNBP2 1q31.3 formin binding protein 2 IKBKE 1q32.1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon RASSF5 1q32.1 Ras association (RalGDS/AF-6) domain family 5 LGTN 1q31-q32 ligatin DYRK3 1q32 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 MAPKAPK2 1q32 mitogen-activated protein kinase-activated protein kinase 2 IL10 1q31.3-q32.1 interleukin 10 IL19 1q32.2 interleukin 19 IL20 1q32 interleukin 20 IL24 1q32 interleukin 24 TOSO 1q32.1 regulator of Fas-induced apoptosis PIGR 1q32 polymeric immunoglobulin receptor FKSG87 1q32.1 FKSG87 protein LOC387623 1 hypothetical gene supported by NM_024115 SARG 1q32.1 specifically androgen-regulated protein DKFZp451J1719 1q32.1 hypothetical DKFZp451J1719 PFKFB2 1q31 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 C4BPB 1q32 complement component 4 binding protein, beta C4BPA 1q32 complement component 4 binding protein, alpha LOC343024 1q32.1 similar to C4BP alpha chain precursor - rabbit C4BPAL2 1q32 complement component 4 binding protein, alpha-like 2 DAF 1q32 decay accelerating factor for complement (CD55, Cromer blood group system) FLJ13310 1q32.1 hypothetical protein FLJ13310 CR2 1q32 complement component (3d/Epstein Barr virus) receptor 2 CR1 1q32 complement component (3b/4b) receptor 1, including Knops blood group system
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1976 23 206 - 2011 21843952
    - splicing 1633 5 48 - 2011 21843952
  • lacking an internal segment compared to variant 1
  • the resulting shorter isoform (2) is identical to the C-terminal region of isoform 1
  • lacking exons 3 and 5
  • 6 - 1820 - 154 - 2011 21843952
    5 - 1621 - 63 - 2011 21843952
    7 - 1979 - 207 - 2011 21843952
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Lymphoid/Immunelymph node   highly
     spleen    
     thymus    
    Reproductivefemale systembreast   
     male systemprostate  moderately
    Respiratorylung   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle
    life cycle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP , ubiquitinated
    HOMOLOGY
    interspecies homolog to rattus Il24
    ortholog to murine Il24
    Homologene
    FAMILY cytokine family (IL10 family)
    CATEGORY tumor suppressor , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • involved in growth control and terminal differentiation in cancer cells, negative regulator of melanoma progression
  • functions potentially during an inflammatory response in the skin by inhibiting the proliferation and migration of keratinocytes
  • specifically inhibits cancer cell growth through the induction of cell cycle arrest and apoptosis
  • suppressed mRNA expression of vascular endothelial growth factor and platelet-derived growth factor and subsequently decreased the level of cell migration in response to H(2)O(2)
  • suppress tumor progression in a variety of human cancers
  • cytokine with potent antitumour and tumour-suppressive activity which functions through its receptor (IL22R)
  • plays a profound role in suppressing tumour lymphangiogenesis, thereby, reducing the likelihood of cancer metastasis via the lymphatic route
  • IL24 and IL19 are involved in host defence against bacteria and fungi, tissue remodelling and wound healing
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK14 is a regulator of IL24 expression and determine interference with destabilization mediated by the 3prime UTR of IL24 mRNA as mode of action
  • STAT6 and JUN proteins were found to physically cooperate with each other and upregulated IL24 gene transcription
  • IL24 reduces VSMC calcification by inhibiting the WNT/CTNNB1 pathway
  • SIGMAR1 is a key initial mediator of IL24 induction of cancer-specific killing
  • cell & other
    REGULATION
    Other ubiquitinated and degraded by the 26S proteasome
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary melanoma in progression to invasive and metastatic stages
    tumoral     --low  
    in breast cancer, is associated with lymphatic metastases and a poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    is a potential therapeutic agent in vascular smooth muscle cell (VSMC) calcification
    ANIMAL & CELL MODELS