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FLASH GENE
Symbol IL24 contributors: mct - updated : 14-12-2013
HGNC name interleukin 24
HGNC id 11346
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Lymphoid/Immunelymph node   highly
 spleen    
 thymus    
Reproductivefemale systembreast   
 male systemprostate  moderately
Respiratorylung   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte Homo sapiens
Lymphoid/ImmuneT cell Homo sapiens
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle
life cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP , ubiquitinated
HOMOLOGY
interspecies homolog to rattus Il24
ortholog to murine Il24
Homologene
FAMILY cytokine family (IL10 family)
CATEGORY tumor suppressor , signaling cytokine
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • involved in growth control and terminal differentiation in cancer cells, negative regulator of melanoma progression
  • functions potentially during an inflammatory response in the skin by inhibiting the proliferation and migration of keratinocytes
  • specifically inhibits cancer cell growth through the induction of cell cycle arrest and apoptosis
  • suppressed mRNA expression of vascular endothelial growth factor and platelet-derived growth factor and subsequently decreased the level of cell migration in response to H(2)O(2)
  • suppress tumor progression in a variety of human cancers
  • cytokine with potent antitumour and tumour-suppressive activity which functions through its receptor (IL22R)
  • plays a profound role in suppressing tumour lymphangiogenesis, thereby, reducing the likelihood of cancer metastasis via the lymphatic route
  • IL24 and IL19 are involved in host defence against bacteria and fungi, tissue remodelling and wound healing
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK14 is a regulator of IL24 expression and determine interference with destabilization mediated by the 3prime UTR of IL24 mRNA as mode of action
  • STAT6 and JUN proteins were found to physically cooperate with each other and upregulated IL24 gene transcription
  • IL24 reduces VSMC calcification by inhibiting the WNT/CTNNB1 pathway
  • SIGMAR1 is a key initial mediator of IL24 induction of cancer-specific killing
  • cell & other
    REGULATION
    Other ubiquitinated and degraded by the 26S proteasome
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary melanoma in progression to invasive and metastatic stages
    tumoral     --low  
    in breast cancer, is associated with lymphatic metastases and a poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    is a potential therapeutic agent in vascular smooth muscle cell (VSMC) calcification
    ANIMAL & CELL MODELS