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FLASH GENE
Symbol HSPA1A contributors: mct/pgu - updated : 02-03-2014
HGNC name heat shock 70kDa protein 1A
HGNC id 5232
Location 6p21.3      Physical location : 3.068.877 - 31.785.717
Synonym name heat shock-induced protein
Synonym symbol(s) HSP70-1, HSP72, HSPA1, HSPA1B, HSP70-1A, FLJ54303, FLJ54370, FLJ54392, FLJ54408, FLJ75127, HSP70-1 1, HSP70-1/HSP70-2
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 2.38 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure binding site for FOXA1 transcription factor
MAPPING cloned Y linked N status confirmed
Map pter - HLA-B - G7 - HSPA1L - HSPA1B - (92kb) - HSPA1A - G8 -C2 C2 - cen
Text see BAT@ ,LTA
Physical map
BAT1 6p21.33 HLA-B associated transcript 1 ATP6V1G2 6p21.3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 2 NFKBIL1 6p21.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 LTA 6p21.3 lymphotoxin alpha (TNF superfamily, member 1) TNF 6p21.3 tumor necrosis factor (TNF superfamily, member 2) LTB 6p21.3 lymphotoxin beta (TNF superfamily, member 3) LST1 6p21.3 leukocyte specific transcript 1 NCR3 6p21.3 natural cytotoxicity triggering receptor 3 AIF1 6p21.3 allograft inflammatory factor 1 BAT2 6p21.33 HLA-B associated transcript 2 BAT3 6p21.33 HLA-B associated transcript 3 APOM 6p21.31 apolipoprotein M C6orf47 6p21.3 chromosome 6 open reading frame 47 BAT4 6p21.33 HLA-B associated transcript 4 CSNK2B 6p21.3 casein kinase 2, beta polypeptide LY6G5B 6p21.3 lymphocyte antigen 6 complex, locus G5B LY6G5C 6p21.3 lymphocyte antigen 6 complex, locus G5C BAT5 6p21.33 HLA-B associated transcript 5 LY6G6D 6p21.3 lymphocyte antigen 6 complex, locus G6D LY6G6E 6p21.3 lymphocyte antigen 6 complex, locus G6E LY6G6C 6p21.3 lymphocyte antigen 6 complex, locus G6C C6orf25 6p21.3 chromosome 6 open reading frame 25 DDAH2 6p21.3 dimethylarginine dimethylaminohydrolase 2 CLIC1 6p21.3 chloride intracellular channel 1 MSH5 6p21.3 mutS homolog 5 (E. coli) C6orf27 6p21.31 chromosome 6 open reading frame 27 VARS2 6p21.3 valyl-tRNA synthetase 2 LSM2 6p21.3 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) HSPA1L 6p21.3 heat shock 70kDa protein 1-like HSPA1A 6p21.3 heat shock 70kDa protein 1A HSPA1B 6p21.3 heat shock 70kDa protein 1B C6orf48 6p21.3 chromosome 6 open reading frame 48 NEU1 6p21.3 sialidase 1 (lysosomal sialidase) C6orf29 6p21.3 chromosome 6 open reading frame 29 BAT8 6p21.31 HLA-B associated transcript 8 C6orf46 6p21.31 chromosome 6 open reading frame 46 C2 6p21.3 complement component 2
regionally located located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins
RNA
TRANSCRIPTS type messenger
text may cause alternative splicing (Shimizu, 1999)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2445 - 641 - 2005 15632129
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver     Homo sapiens
Endocrineadrenal gland     Homo sapiens
 pancreas     Homo sapiens
Lymphoid/Immunelymph node     Homo sapiens
Nervousnerve   highly
Reproductivefemale systembreast    Homo sapiens
Respiratorydiaphragm     Homo sapiens
 lung     Homo sapiens
Urinarybladder     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
Muscularstriatumcardiac   Homo sapiens
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
conjugated PhosphoP
HOMOLOGY
interspecies homolog to rattus Hspa1b (96.4 pc)
homolog to murine Hspa1b (95.2 pc)
Homologene
FAMILY
  • heat shock protein 70 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • stabilizing preexistent proteins against aggregation
  • mediating the folding of newly translated polypeptides in the cytosol as well as within organelles
  • being able to recognize nonnative conformations of other proteins
  • involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1
  • blocking heat-induced apoptosis primarily by inhibiting Bax activation via the inhibition of stress-induced JNK activation
  • acting upstream of the mitochondria to inhibit Fas-mediated apoptosis
  • protecting GATA-1 from caspase-mediated proteolysis
  • extracellular HSPBP1 and HSPA1A synergistically activate epidermal growth factor receptor
  • playing an essential role in blocking inflammation and preventing insulin resistance in the context of genetic obesity or high-fat feeding
  • has an essential role in ERBB2-induced tumorigenesis by regulating oncogene-induced senescence pathways
  • role for the HSPA1A-PARK2 axis in the regulation of muscle insulin sensitivity
  • CELLULAR PROCESS cell life, antiapoptosis
    protein, post translation, folding
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text
  • response to unfolded protein
  • PATHWAY
    metabolism other
    signaling
    mRNA catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • SOX9 in chondrocytes and testicular cell lines
  • interacting with TSC2
  • interaction with HNRPD
  • binding extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage
  • binding to ERN1 enhances ERN1/XBP1 signaling at the ER and inhibits ER stress-induced apoptosis
  • HSPA1A stabilizes the WASF3 protein
  • interacts with ATP2A1 to preserve its function under conditions of stress, ultimately contributing to the decreased muscle degeneration seen with HSPA1A upregulation
  • HSPA1A and CLEC14A interact on endothelial cells and this interaction regulates HSPA1A-induced angiogenesis
  • cell & other
    REGULATION
    induced by IL6 in skeletal muscle
    inhibited by quercetin
    Other up-regulated by FOXA1 in MCF7 breast cancer cell line
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    low expressed in gastric cancer
    constitutional     --over  
    in preeclampsia, and serum HSPA1A levels reflect systemic inflammation, oxidative stress and hepatocellular injury, but is significantly higher in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome) than in severely preeclamptic patients without HELLP syndrome
    Susceptibility
  • to coronary heart disease (CHD)
  • to Meniere disease (MD)
  • Variant & Polymorphism other
  • +190CC genotype was associated with significantly higher risk of CHD
  • frequency of having at least one 190C allele was significantly higher in the MD patients than the controls
  • Candidate gene
    Marker
    Therapy target potential target for therapeutic treatment of obesity-induced insulin resistance
    SystemTypeDisorderPubmed
    neuromuscularmyopathy 
    increasing the expression of HSPA1A in muscle has significant therapeutic potential for DMD and related conditions
    diabete  
    HSPA1A is a potential treatment to prevent Beta-cell mass decline in type 2 diabetic patients
    ANIMAL & CELL MODELS