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FLASH GENE

Symbol

HSPA1B

contributors: mct/ - updated : 25-01-2007

HGNC name	heat shock 70kDa protein 1B
HGNC id	5233

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.32      Physical location : 3.081.098 - 31.798.031
Synonym name	heat shock 70 kDa protein 1A/1B
Synonym symbol(s)	HSP70-2, HSPA1A, FLJ54328

DNA

TYPE	functioning gene
STRUCTURE	2.52 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	see HTFAG@

regionally located

in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005346 1 - 2551 NP_005337 - 641 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Lymphoid/Immune spleen       highly Respiratory respiratory tract trachea     moderately Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Hspa1b (96.4 pc)
	homolog to murine Hspa1b (95.2 pc)
	homolog to Drosophila Hsp70Ab (76.2 pc)

Homologene

FAMILY

heat shock protein 70 family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,nucleus

basic FUNCTION	involved in tumor immunity and cancer pathogenesis
	stabilizing existing proteins against aggregation
	mediating the folding of newly translated proteins in the cytosol and in organelles
	involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1
	possible role of FKBP6 and HSPA1B in the disassembly of clathrin coats

CELLULAR PROCESS	cell life, antiapoptosis
	protein, post translation, folding

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

mRNA catabolism

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	unfolded protein
	interaction with HNRPD
	interacting with FKBP6

cell & other

REGULATION

induced by

heat shock

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to nasopharyngeal carcinoma (NPC) (homozygous genotype P2/P2 may be a marker of increased risk in Tunisians) to obesity

Variant & Polymorphism SNP	SNP rs1061581 associated to risk of obesity

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS