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FLASH GENE
Symbol DSPP contributors: mct/npt/pgu - updated : 08-10-2013
HGNC name dentin sialophosphoprotein
HGNC id 3054
Corresponding disease
DFNA39 neurosensory deafness 39
DGI1 dentinogenesis imperfecta 1
Location 4q22.1      Physical location : 88.529.680 - 88.538.023
Synonym name
  • dentin phosphoryn
  • dentin sialoprotein
  • Synonym symbol(s) DPP, DMP3, DSP, DTDP2, DFNA39, DGI1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text
  • bicistronic, coding for DSP (exon 1-4), DPP (exon 4-6)
  • SIBLINGs share many common features, such as their tandem gene location
  • STRUCTURE 8.34 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    DKFZP564B1162 4q22.1 hypothetical protein DKFZp564B1162 MAPK10 4q21-q22 mitogen-activated protein kinase 10 PTPN13 4q21.3 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) SOAT 4q22.1 sodium-dependent organic anion transporter MGC26744 4q22.1 hypothetical protein MGC26744 LOC260422 4q21.3 actin related protein 2/3 complex subunit 1A pseudogene LOC389210 4 similar to hypothetical protein LOC391676 4 similar to Synaptic glycoprotein SC2 MLLT2 4q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 KLHL8 4q22.1 kelch-like 8 (Drosophila) GAPDL4 4pter-p16.2 glyceraldehyde-3-phosphate dehydrogenase-like 4 SCDR9 4q22.1 short-chain dehydrogenase/reductase 9 DHRS8 4q22.1 dehydrogenase/reductase (SDR family) member 8 NUDT9 4q21.3 nudix (nucleoside diphosphate linked moiety X)-type motif 9 SPARCL1 4q27 SPARC-like 1 (mast9, hevin) DSPP 4q21.3 dentin sialophosphoprotein DMP1 4q21.2-q21.3 dentin matrix acidic phosphoprotein LOC391677 4 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein IBSP 4q21-q25 integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) MEPE 4q21.1 matrix, extracellular phosphoglycoprotein with ASARM motif (bone) HSPCP1 4q21-q25 heat shock 90kDa protein 1, beta pseudogene 1 SPP1 4q21-q25 secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) PKD2 4q22 polycystic kidney disease 2 (autosomal dominant) ABCG2 4q22 ATP-binding cassette, sub-family G (WHITE), member 2 DKFZp761G058 4q22.1 hypothetical protein DKFZp761G058 CEB1 4q22.1-q23 hypothetical protein DKFZp761G058 MGC14156 4q22.1 hypothetical protein MGC14156 HERC3 4q21 hect domain and RLD 3 DRLM FAM13A1 4q21 family with sequence similarity 13, member A1 LOC389211 4 similar to expressed sequence AW060714 TIGD2 4q21.3 tigger transposable element derived 2 LOC285513 4q22.1 hypothetical protein LOC285513
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4331 47.4 1301 - 2008 1881991
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtoothcement   Homo sapiens
     mouthtoothenamel   Homo sapiens
     salivary gland     Homo sapiensAdult
    Respiratorylung     Homo sapiensAdult
    Urinarykidney     Homo sapiensAdult
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveameloblast Homo sapiens
    Digestiveodontoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • at the N terminus, RGD attachment motif and aspartate-serine region homolog to the repeated motif ARSAM found on MEPE, that can bind to integrins on the cell surface of undifferentiated mesenchymal stem cells and pulp cells
  • DSP domain is found at the N-terminus (exons 1-4 and the 5' region of exon 5)
  • the DPP sequence at the COOH portion (remainder of exon 5)
  • hydrophobic signal peptide motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Dspp
    Homologene
    FAMILY
  • SIBLING (small integrin-binding ligand, N-linked glycoprotein) family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • precursor of dentin sialoprotein (DSP) and dentin phosphoprotein
  • non-collagenous protein in dentin, which is highly phosphorylated and plays key roles in dentin biomineralisation
  • regulating the gene expression and differentiation of mesenchymal stem cells via the integrin/MAPK signaling pathway
  • plays a crucial role in tooth development and mineralization, in particular dentinogenesis, and is one of the key markers during odontoblast differentiation
  • differential biological functions of RUNX2, SP7, and DSPP during odontogenesis and osteogenesis
  • DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
  • extracellular DSPP can induce intracellular signaling that can be propagated to the nucleus and thus alter gene activities
  • plays potentially a major role in anchorage-dependent signaling events
  • extracellular DSPP can provide a tight association between the structural and signaling elements in undifferentiated mesenchymal cells
  • major noncollagenous protein in the dentin matrix
  • is potentially capable of triggering commitment of pluripotent stem cells to the osteogenic lineage
  • plays a major role in the mineralization of dentin
  • in the odontoblasts, its primary function is in the extracellular mineralization of dentin, whereas in the kidney it may participate in calcium transport
  • positively affects mineral formation, and odontoblast-like differentiation and maturation of Dental pulp stem cells (DPSCs) can be regulated by histone acetylation of the DSPP gene
  • continuous DSPP action is required for the growth and/or maintenance of the mandibular condylar cartilage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
  • non collagenous consistent of the dentin extra-cellular matrix
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulated by DMP1 ((association of DMP1 with the DSPP promoter, providing the foundation to understand how DMP1 regulates the expression of the DSPP gene)
  • downstream effector molecule that mediates the roles of DMP1 in dentinogenesis
  • cell & other
    REGULATION
    activated by BMP2 (activates DSPP gene transcription via NF-Y signaling, and this BMP2-NF-Y-DSPP pathway plays an important role in odontoblast differentiation)
    repressed by regulated by WNT10A (an upstream regulatory molecule for DSPP expression
    Other proteolytic processing of DSPP is an activation step essential to its biological function in dentinogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s) DGI1 , DFNA39
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dspp knock-out mice displayed dentin defects with less mineralized dentin and wider unmineralized predentin
  • Dspp null mice exhibited decreases in the amount of MCC (mandibular condylar cartilage), with reduced formation of articular and prechondroblastic layers in which progenitor cell proliferation levels were distinctly affected