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FLASH GENE
Symbol DSPP contributors: mct/npt/pgu - updated : 08-10-2013
HGNC name dentin sialophosphoprotein
HGNC id 3054
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4331 47.4 1301 - 2008 1881991
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtoothcement   Homo sapiens
 mouthtoothenamel   Homo sapiens
 salivary gland     Homo sapiensAdult
Respiratorylung     Homo sapiensAdult
Urinarykidney     Homo sapiensAdult
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveameloblast Homo sapiens
Digestiveodontoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • at the N terminus, RGD attachment motif and aspartate-serine region homolog to the repeated motif ARSAM found on MEPE, that can bind to integrins on the cell surface of undifferentiated mesenchymal stem cells and pulp cells
  • DSP domain is found at the N-terminus (exons 1-4 and the 5' region of exon 5)
  • the DPP sequence at the COOH portion (remainder of exon 5)
  • hydrophobic signal peptide motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Dspp
    Homologene
    FAMILY
  • SIBLING (small integrin-binding ligand, N-linked glycoprotein) family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • precursor of dentin sialoprotein (DSP) and dentin phosphoprotein
  • non-collagenous protein in dentin, which is highly phosphorylated and plays key roles in dentin biomineralisation
  • regulating the gene expression and differentiation of mesenchymal stem cells via the integrin/MAPK signaling pathway
  • plays a crucial role in tooth development and mineralization, in particular dentinogenesis, and is one of the key markers during odontoblast differentiation
  • differential biological functions of RUNX2, SP7, and DSPP during odontogenesis and osteogenesis
  • DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
  • extracellular DSPP can induce intracellular signaling that can be propagated to the nucleus and thus alter gene activities
  • plays potentially a major role in anchorage-dependent signaling events
  • extracellular DSPP can provide a tight association between the structural and signaling elements in undifferentiated mesenchymal cells
  • major noncollagenous protein in the dentin matrix
  • is potentially capable of triggering commitment of pluripotent stem cells to the osteogenic lineage
  • plays a major role in the mineralization of dentin
  • in the odontoblasts, its primary function is in the extracellular mineralization of dentin, whereas in the kidney it may participate in calcium transport
  • positively affects mineral formation, and odontoblast-like differentiation and maturation of Dental pulp stem cells (DPSCs) can be regulated by histone acetylation of the DSPP gene
  • continuous DSPP action is required for the growth and/or maintenance of the mandibular condylar cartilage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
  • non collagenous consistent of the dentin extra-cellular matrix
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulated by DMP1 ((association of DMP1 with the DSPP promoter, providing the foundation to understand how DMP1 regulates the expression of the DSPP gene)
  • downstream effector molecule that mediates the roles of DMP1 in dentinogenesis
  • cell & other
    REGULATION
    activated by BMP2 (activates DSPP gene transcription via NF-Y signaling, and this BMP2-NF-Y-DSPP pathway plays an important role in odontoblast differentiation)
    repressed by regulated by WNT10A (an upstream regulatory molecule for DSPP expression
    Other proteolytic processing of DSPP is an activation step essential to its biological function in dentinogenesis
    ASSOCIATED DISORDERS
    corresponding disease(s) DGI1 , DFNA39
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dspp knock-out mice displayed dentin defects with less mineralized dentin and wider unmineralized predentin
  • Dspp null mice exhibited decreases in the amount of MCC (mandibular condylar cartilage), with reduced formation of articular and prechondroblastic layers in which progenitor cell proliferation levels were distinctly affected