basic FUNCTION
| precursor of dentin sialoprotein (DSP) and dentin phosphoprotein |
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non-collagenous protein in dentin, which is highly phosphorylated and plays key roles in dentin biomineralisation |
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regulating the gene expression and differentiation of mesenchymal stem cells via the integrin/MAPK signaling pathway |
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plays a crucial role in tooth development and mineralization, in particular dentinogenesis, and is one of the key markers during odontoblast differentiation |
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differential biological functions of RUNX2, SP7, and DSPP during odontogenesis and osteogenesis |
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DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis |
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extracellular DSPP can induce intracellular signaling that can be propagated to the nucleus and thus alter gene activities |
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plays potentially a major role in anchorage-dependent signaling events |
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extracellular DSPP can provide a tight association between the structural and signaling elements in undifferentiated mesenchymal cells |
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major noncollagenous protein in the dentin matrix |
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is potentially capable of triggering commitment of pluripotent stem cells to the osteogenic lineage |
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plays a major role in the mineralization of dentin |
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in the odontoblasts, its primary function is in the extracellular mineralization of dentin, whereas in the kidney it may participate in calcium transport |
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positively affects mineral formation, and odontoblast-like differentiation and maturation of Dental pulp stem cells (DPSCs) can be regulated by histone acetylation of the DSPP gene |
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continuous DSPP action is required for the growth and/or maintenance of the mandibular condylar cartilage |