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FLASH GENE
Symbol DSPP contributors: mct/npt/pgu - updated : 08-10-2013
HGNC name dentin sialophosphoprotein
HGNC id 3054
ASSOCIATED DISORDERS
corresponding disease(s) DGI1 , DFNA39
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Dspp knock-out mice displayed dentin defects with less mineralized dentin and wider unmineralized predentin
  • Dspp null mice exhibited decreases in the amount of MCC (mandibular condylar cartilage), with reduced formation of articular and prechondroblastic layers in which progenitor cell proliferation levels were distinctly affected