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FLASH GENE

Symbol

DAO

contributors: mct - updated : 20-08-2010

HGNC name	D-amino-acid oxidase
HGNC id	2671

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ALS13 amyotrophic lateral sclerosis 13 SCZD23 schizophrenia 23
Location	12q24.11      Physical location : 109.273.856 - 109.294.709
Synonym symbol(s)	DAAO, OXDA, DAMOX, MGC35381
EC.number	1.4.3.3

DNA

TYPE	functioning gene
STRUCTURE	20.85 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - PAH - IGF1 - ASCL1 - NFYB - TRA1 - DAO ,NOS1 - qter
Authors	Renault (94)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001917 11 - 1626 NP_001908 39.3 347 - Chassande (1994)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Nervous brain       highly   spinal cord       highly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Dao1

Homologene

FAMILY

DAMOX family

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,peroxisome

basic FUNCTION	D-amino-oxidase, glycine oxidase catalyzing the oxidative deomination glycine to of glyoxylate
	peroxisomal flavin adenine dinucleotide (FAD)-dependent oxidase (Mitchell 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

aminoacid

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	flavin adenine denucleotide (FAD)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCZD23 , ALS13

Susceptibility

to schizophrenia

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS