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FLASH GENE
Symbol NFYB contributors: mct - updated : 18-03-2011
HGNC name nuclear transcription factor Y, beta
HGNC id 7805
Location 12q23.3      Physical location : 104.510.857 - 104.532.040
Synonym name
  • CCAAT-binding transactivation factor,beta subunit
  • Synonym symbol(s) HAP3, CBF-A, CBF-B, NF-YB
    DNA
    TYPE functioning gene
    STRUCTURE 18.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen -D12S1859 - PAH - D12S1104 - (D12S1841 ,D12S1258 ) - D12S815 - D12S1105 - D12S360 - D12S1317 - (TRA1 - D12S1326 ,D12S1255 ,D12S806 ,D12S78 - D12S800 ) - NFYB - D12S1106 - D12S338 - (D12S1844 ,D12S1826 ) - (D12S1075 ,D12S1647 ) - D12S1636 - (D12S317 ,D12S1597 ) - D12S1176E - D12S1342 - D12S1412 - D12S1848 - D12S330 - D12S1107 - D12S1613 - D12S1109 - D12S1128 - D12S1110 - qter
    Authors Renault (94),4st Workshop chrom.12 (97)
    Physical map
    LOC387880 12 similar to 10 KD HEAT SHOCK PROTEIN, MITOCHONDRIAL (HSP10) (10 KD CHAPERONIN) (CPN10) FLJ11259 12q23.3 hypothetical protein FLJ11259 LOC390353 12 similar to ribosomal protein L9 CGI-116 12q23.3 CGI-116 protein Nup37 12q23.3 nucleoporin Nup37 FLJ20641 12q23.3 hypothetical protein FLJ20641 PMCH 12q23.1 pro-melanin-concentrating hormone IGF1 12q23.1 insulin-like growth factor 1 (somatomedin C) PAH 12q23.1 phenylalanine hydroxylase ASCL1 12q23.1 achaete-scute complex-like 1 (Drosophila) FLJ25323 12q23.3 FLJ25323 protein STAB2 12q33.3 stabilin 2 TU12B1-TY 12q22-q23.1 TU12B1-TY protein LOC253724 12q23.3 hypothetical LOC253724 LOC283350 12q23.3 similar to cDNA sequence BC030307 TRA1 12q23.1 tumor rejection antigen (gp96) 1 LOC387881 12 LOC387881 TDG 12q22-24.1 thymine-DNA glycosylase LOC83468 12q gycosyltransferase HCF-2 12q23.3 host cell factor 2 NFYB 12q22-q23 nuclear transcription factor Y, beta LOC390354 12 similar to ribosomal protein L18a; 60S ribosomal protein L18a TXNRD1 12q23-q24 thioredoxin reductase 1 CHST11 12q23.2-q23.3 carbohydrate (chondroitin 4) sulfotransferase 11 DKFZP434K0427 12q24.11 hypothetical protein DKFZp434K0427 LOC121054 12q24.11 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MGC40397 12q24.11 hypothetical protein MGC40397 FLJ38508 12q24.11 hypothetical protein FLJ38508 KIAA1033 12q24.11 KIAA1033 protein DIP13B 12q24.1 DIP13 beta LOC387882 12 hypothetical gene supported by AJ311377; BC013920 LOC390355 12 similar to dynein, axonemal, heavy chain 11; situs inversus viscerum; dynein, axon, heavy chain 11 LOC245718 12q24.11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein ARK5 12q24.11 AMP-activated protein kinase family member 5 LOC341378 12q24.11 similar to thyroid hormone receptor interactor 11; thyroid receptor interacting protein 11 CKAP4 12q24.11 cytoskeleton-associated protein 4 MGC40368 12q24.11 hypothetical protein MGC40368 RPC2 12q24.11 RNA polymerase III subunit RPC2
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a N terminal A domain,a highly conserved central B domain involved in DNA binding,a C terminal C domain rich in glutamine and acidic residues involved in protein-protein interactions
    HOMOLOGY
    intraspecies homolog to H2B
    Homologene
    FAMILY cbf-a subfamily
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • essential for expression of the proapoptotic BCL2L11 gene in sympathetic neurons
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming a trimeric complex with NFYB and NFYC
    INTERACTION
    DNA binding to the CCAAT and the inverted CCAT-box,Y-box (ATGG) motifs in a variety of promoters
    RNA
    small molecule
    protein
  • interacting with SARS2 (NFYA, NFYB, NFYC influences directionality of transcription from the bidirectional MRPS12/SARS2 promoter)
  • NFYA, NFYB, NFYC, cooperates with FOXO3 to recruit EP300 to the BCL2L11 promoter to form a stable multi-protein/DNA complex that activates BCL2L11 transcription after survival factor withdrawal
  • NFYA, NFYB, NFYC can act as a transcriptional activator of ABCB4
  • cell & other
    REGULATION
    activated by ATF6
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    impaired cells from exiting G2/M, but did not interfere with S-phase progression (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS