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FLASH GENE
Symbol NFYB contributors: mct - updated : 18-03-2015
HGNC name nuclear transcription factor Y, beta
HGNC id 7805
Location 12q23.3      Physical location : 104.510.857 - 104.532.040
Synonym name
  • CCAAT-binding transactivation factor,beta subunit
    • Synonym symbol(s) HAP3, CBF-A, CBF-B, NF-YB
    DNA
    TYPE functioning gene
    STRUCTURE 18.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen -D12S1859 - PAH - D12S1104 - (D12S1841 ,D12S1258 ) - D12S815 - D12S1105 - D12S360 - D12S1317 - (TRA1 - D12S1326 ,D12S1255 ,D12S806 ,D12S78 - D12S800 ) - NFYB - D12S1106 - D12S338 - (D12S1844 ,D12S1826 ) - (D12S1075 ,D12S1647 ) - D12S1636 - (D12S317 ,D12S1597 ) - D12S1176E - D12S1342 - D12S1412 - D12S1848 - D12S330 - D12S1107 - D12S1613 - D12S1109 - D12S1128 - D12S1110 - qter
    Authors Renault (94),4st Workshop chrom.12 (97)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a N terminal A domain,a highly conserved central B domain involved in DNA binding,a C terminal C domain rich in glutamine and acidic residues involved in protein-protein interactions
    HOMOLOGY
    intraspecies homolog to H2B
    Homologene
    FAMILY cbf-a subfamily
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • essential for expression of the proapoptotic BCL2L11 gene in sympathetic neurons
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming a trimeric complex with NFYB and NFYC
    INTERACTION
    DNA binding to the CCAAT and the inverted CCAT-box,Y-box (ATGG) motifs in a variety of promoters
    RNA
    small molecule
    protein
  • interacting with SARS2 (NFYA, NFYB, NFYC influences directionality of transcription from the bidirectional MRPS12/SARS2 promoter)
  • NFYA, NFYB, NFYC, cooperates with FOXO3 to recruit EP300 to the BCL2L11 promoter to form a stable multi-protein/DNA complex that activates BCL2L11 transcription after survival factor withdrawal
  • NFYA, NFYB, NFYC can act as a transcriptional activator of ABCB4
  • NFYA, NFYB, NFYC and YY1 are important for the basal transcription of PCYT2 and NFY is involved in the inhibitory effects of 25-HC on PCYT2 transcription
    • cell & other
    REGULATION
    activated by ATF6
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    impaired cells from exiting G2/M, but did not interfere with S-phase progression (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS