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FLASH GENE
Symbol CCR4 contributors: mct - updated : 04-02-2012
HGNC name chemokine (C-C motif) receptor 4
HGNC id 1605
Location 3p22.3      Physical location : 32.993.065 - 32.996.403
Synonym name small inducible cytokine, high affinity specific receptor for SCYA17 (TARC), expressed TC in skin but not in intestine
Synonym symbol(s) CMKBR4, CC-CKR-4, K5-5, CKR4
DNA
TYPE functioning gene
STRUCTURE 3.34 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC339897 3p22.3 similar to calponin 2; Calonin 2 LOC391524 3 similar to Thyroid hormone receptor-associated protein complex 150 kDa component (Trap150) SIMP 3p22.3 source of immunodominant MHC-associated peptides OSBPL10 3p22.3 oxysterol binding protein-like 10 LOC344787 3p22.3 similar to KIAA2033 protein KIAA0089 3p22.3 similar to KIAA2033 protein LOC391525 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) CKLFSF8 3p22.3 chemokine-like factor super family 8 CKLFSF7 3p22.3 chemokine-like factor super family 7 CKLFSF6 3p22.3 chemokine-like factor super family 6 LOC285260 3p22.3 similar to ribosomal protein L31 DNCLI1 3p22.2 dynein, cytoplasmic, light intermediate polypeptide 1 LOC391526 3 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) CNOT10 3p22.3 CCR4-NOT transcription complex, subunit 10 LOC389101 3 similar to 60S ribosomal protein L23a LOC389102 3 similar to YPLR6490 LOC131405 3p22.3 similar to abnormal cell LINeage LIN-41, heterochronic gene; Drosophila dappled/ vertebrate TRipartite Motif protein related; B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41) CCR4 3p24 chemokine (C-C motif) receptor 4 LOC389103 3 LOC389103 GLB1 3p21.33 galactosidase, beta 1 CRTAP 3p22 cartilage associated protein KIAA0527 3p22.3 KIAA0527 protein FBXL2 3p24.3 F-box and leucine-rich repeat protein 2 UBP1 3p22.2 upstream binding protein 1 (LBP-1a) CLASP2 3p24.2-p21.33 cytoplasmic linker associated protein 2 LOC389104 3 similar to CLIP-associating protein 1; multiple asters 1 PDCD6IP 3p22.3 programmed cell death 6 interacting protein LOC285307 3p22.2 hypothetical LOC285307 FECHP 3p23-p22 ferrochelatase pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1657 - 360 - 1999 10466728
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connectiveadipose  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Blood/Hematopoieticplatelet
Lymphoid/Immunelymphocyte Homo sapiens
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Cmkbr4
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY signaling , receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • preferentially expressed on Th2 lymphocytes
  • basic FUNCTION
  • specific receptor for thymus and activation-regulated chemokine
  • plays an important role in T reg cell trafficking in lymph nodes and this is critical for T reg cell suppressive function
  • CCR4 and CCR10 are expressed on epidermal keratinocytes and both are functional in terms of skin cytokine production and/or migration to their ligand CCL17 and CCL27, respectively
  • associated with trafficking of specialized cutaneous memory type 2 T(h) cells in the skin
  • involvement of CCR4 in inflammatory macrophage effector function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand CCL17 (CCR4/CCL17)
  • CKLF with its C-terminal peptides can interact with CCR4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in skin and lymph nodes of adult T-cell leukemia
    tumoral     --other  
    aberrant expression of CCR4 in gastric cancer could contribute to tumor-induced immunosuppression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    downmodulation of CCR4 expression could be a promising immunotherapy for human gastric cancer
    allergy  
    blocking CCR4-ligand interaction may provide a novel therapeutic approach in allergic disease
    ANIMAL & CELL MODELS