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FLASH GENE
Symbol CCR4 contributors: mct - updated : 04-02-2015
HGNC name chemokine (C-C motif) receptor 4
HGNC id 1605
Location 3p22.3      Physical location : 32.993.065 - 32.996.403
Synonym name small inducible cytokine, high affinity specific receptor for SCYA17 (TARC), expressed TC in skin but not in intestine
Synonym symbol(s) CMKBR4, CC-CKR-4, K5-5, CKR4
DNA
TYPE functioning gene
STRUCTURE 3.34 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1657 - 360 - 1999 10466728
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connectiveadipose  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Blood/Hematopoieticplatelet
Lymphoid/Immunelymphocyte Homo sapiens
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Cmkbr4
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY signaling , receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • preferentially expressed on Th2 lymphocytes
    • basic FUNCTION
  • specific receptor for thymus and activation-regulated chemokine
  • plays an important role in T reg cell trafficking in lymph nodes and this is critical for T reg cell suppressive function
  • CCR4 and CCR10 are expressed on epidermal keratinocytes and both are functional in terms of skin cytokine production and/or migration to their ligand CCL17 and CCL27, respectively
  • associated with trafficking of specialized cutaneous memory type 2 T(h) cells in the skin
  • involvement of CCR4 in inflammatory macrophage effector function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand CCL17 (CCR4/CCL17)
  • CKLF with its C-terminal peptides can interact with CCR4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in skin and lymph nodes of adult T-cell leukemia
    tumoral     --other  
    aberrant expression of CCR4 in gastric cancer could contribute to tumor-induced immunosuppression
    constitutional     --over  
    in Parkinson disease (PD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    downmodulation of CCR4 expression could be a promising immunotherapy for human gastric cancer
    allergy  
    blocking CCR4-ligand interaction may provide a novel therapeutic approach in allergic disease
    ANIMAL & CELL MODELS