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FLASH GENE
Symbol CCR8 contributors: mct/npt - updated : 28-10-2011
HGNC name chemokine (C-C motif) receptor 8
HGNC id 1609
Location 3p22.1      Physical location : 39.371.196 - 39.375.171
Synonym name
  • chemokine (C-C) receptor-like 2
  • CC-chemokine receptor CHEMR1
  • Synonym symbol(s) CMKBR8, CKR-L1, TER1, CY6, CKRL1, CMKBRL2, GPR-CY6, CDw198, CC-CKR-8, MGC129966, MGC129973
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 3.97 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SCN11A 3p24-p21 sodium channel, voltage-gated, type XI, alpha KIAA1449 3p21.33 WD repeat endosomal protein GORASP1 3p22-p21.33 golgi reassembly stacking protein 1, 65kDa STI2 3p21.33 TPR domain containing STI2 AXUD1 3p22 AXIN1 up-regulated 1 CMYA1 3p21.33 cardiomyopathy associated 1 CX3CR1 3p21.32-p21.31 chemokine (C-X3-C motif) receptor 1 CCR8 3p21.32-p21.31 chemokine (C-C motif) receptor 8 hnRNPA1p 3p21.33 heterogeneous nuclear ribonucleoprotein A1 pseudogene LOC389109 3 similar to elongation factor 1 alpha LOC389110 3 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC389111 3 similar to RIKEN cDNA 1110038F21 FLJ20551 3p21.33 hypothetical protein FLJ20551 LAMR1 3p21.3 laminin receptor 1 (ribosomal protein SA, 67kDa) MOBP 3p22-p21.33 myelin-associated oligodendrocyte basic protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1487 40.7 355 - 2006 17023422
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
     thymus    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/HematopoieticNK cell
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cmkbr8
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play an important role in vessel wall pathology
  • mast cell-derived CCL1- and CCR8-expressing CD4(+) effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses
  • in the complex microenvironment in the allergic lung both eosinophils as well as T cells can be potentially recruited to the site of inflammation in response to CCL1 through CCR8
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation
  • CCR8 ligands are allotropic, binding to distinct sites within CCR8 and the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand
  • have only one major mammalian ligand, namely CCL1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS