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FLASH GENE
Symbol CCL20 contributors: mct/npt - updated : 15-04-2008
HGNC name chemokine (C-C motif) ligand 20
HGNC id 10619
Location 2q36.3      Physical location : 228.678.557 - 228.682.280
Synonym name
  • macrophage inflammatory protein 3 alpha
  • small inducible cytokine subfamily A (Cys-Cys), member 20
  • exodus 1
  • liver and activation-regulated chemokine
    • Synonym symbol(s) LARC, MIP3A, SY20, SCYA20, CKb4, ST38, exodus-1
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 799 10.7 96 T-lymphocytes, monocytes Nelson, Meloni (2008)
    - splicing 796 - 95 liver Nelson
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   predominantly
     intestinesmall intestine  lowly
     mouth    
     pharynx   predominantly
    Lymphoid/Immunelymph node   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text predominantly in fetal lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Scy20
    Homologene
    FAMILY
  • intercrine beta family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having antibacterial activity of great potency
  • chemotactic factor attracting lymphocytes and, slightly, neutrophils, but not monocytes
  • having the ability to stimulate odontoblast differentiation in addition to role in inflammation
  • earlier inducer of osteoclast differentiation by increasing the number of pre-osteoclasts, thus favoring cell fusion and MMP9 release
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text inflammatory response
    PATHWAY
    metabolism
    signaling
    a component
  • CCL20/CCR6 system may be involved in hepatocarcinogenesis
    • INTERACTION
    DNA
    RNA
    small molecule
  • in U937 cell line and bones melanoma
  • repressed by IL-10
    • protein
  • interacting with CCR6 (activating CCR6)
    • cell & other
    REGULATION
    induced by lipopolysaccharide (LPS)
    tumor necrosis factor (TNF)
    interferon-gamma
    phorbol myristate acetate (PMA) in U397 cell line and Bowes melanoma
    repressed by IL-10
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    constitutional     --over  
    in rheumatoid arthritis subchondral bone tissue biopsies
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS