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FLASH GENE
Symbol CCL20 contributors: mct/npt - updated : 15-04-2008
HGNC name chemokine (C-C motif) ligand 20
HGNC id 10619
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
Binding site
MAPPING cloned Y linked N status provisional
Physical map
CUL3 2q36.3 cullin 3 DOCK10 2q24.1-q36.3 dedicator of cytokinesis 10 KIAA1486 2q36.3 KIAA1486 protein IRS1 2q36 insulin receptor substrate 1 DKFZp547E052 2q36.3 hypothetical protein DKFZp547E052 COL4A4 2q35-q37.1 collagen, type IV, alpha 4 COL4A3 2q37.1 collagen, type IV, alpha 3 (Goodpasture antigen) LOC389077 2 LOC389077 GL004 2q37.1 LOC389077 FLJ22800 2q36.3 hypothetical protein FLJ22800 HRB 2q36 HIV-1 Rev binding protein DKFZp547H025 2q36.3 hypothetical protein DKFZp547H025 LOC389078 2 hypothetical gene supported by AK125767 SLC19A3 2q37 solute carrier family 19, member 3 CCL20 2q35-q36 chemokine (C-C motif) ligand 20 FLJ25955 2q36.3 hypothetical protein FLJ25955 SKIP 17p13 hypothetical protein FLJ25955 FLJ20701 2q37.1 hypothetical protein FLJ20701 DNER 2q37.1 delta-notch-like EGF repeat-containing transmembrane TRIP12 2q36.1 thyroid hormone receptor interactor 12 LOC130888 FLJ30794 SP110 2q37.1 SP110 nuclear body protein SP140 2q36.1 SP140 nuclear body protein LOC93349 2q37.1 hypothetical protein BC004921 SP100 2q37.1 nuclear antigen SP100 HMG1L3 2q35 high-mobility group (nonhistone chromosomal) protein 1-like 3 LOC389079 2 similar to tropomyosin 3 LOC391489 2 similar to LOC93349 protein MO25 2q37.1 MO25 protein ITM2C 2q37 integral membrane protein 2C GPR55 2q37 G protein-coupled receptor 55 TSARG1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 799 10.7 96 T-lymphocytes, monocytes Nelson, Meloni (2008)
- splicing 796 - 95 liver Nelson
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   predominantly
 intestinesmall intestine  lowly
 mouth    
 pharynx   predominantly
Lymphoid/Immunelymph node   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text predominantly in fetal lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Scy20
Homologene
FAMILY
  • intercrine beta family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having antibacterial activity of great potency
  • chemotactic factor attracting lymphocytes and, slightly, neutrophils, but not monocytes
  • having the ability to stimulate odontoblast differentiation in addition to role in inflammation
  • earlier inducer of osteoclast differentiation by increasing the number of pre-osteoclasts, thus favoring cell fusion and MMP9 release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text inflammatory response
    PATHWAY
    metabolism
    signaling
    a component
  • CCL20/CCR6 system may be involved in hepatocarcinogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
  • in U937 cell line and bones melanoma
  • repressed by IL-10
  • protein
  • interacting with CCR6 (activating CCR6)
  • cell & other
    REGULATION
    induced by lipopolysaccharide (LPS)
    tumor necrosis factor (TNF)
    interferon-gamma
    phorbol myristate acetate (PMA) in U397 cell line and Bowes melanoma
    repressed by IL-10
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    constitutional     --over  
    in rheumatoid arthritis subchondral bone tissue biopsies
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS