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FLASH GENE
Symbol CCL20 contributors: mct/npt - updated : 15-04-2008
HGNC name chemokine (C-C motif) ligand 20
HGNC id 10619
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 799 10.7 96 T-lymphocytes, monocytes Nelson, Meloni (2008)
- splicing 796 - 95 liver Nelson
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   predominantly
 intestinesmall intestine  lowly
 mouth    
 pharynx   predominantly
Lymphoid/Immunelymph node   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text predominantly in fetal lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Scy20
Homologene
FAMILY
  • intercrine beta family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having antibacterial activity of great potency
  • chemotactic factor attracting lymphocytes and, slightly, neutrophils, but not monocytes
  • having the ability to stimulate odontoblast differentiation in addition to role in inflammation
  • earlier inducer of osteoclast differentiation by increasing the number of pre-osteoclasts, thus favoring cell fusion and MMP9 release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text inflammatory response
    PATHWAY
    metabolism
    signaling
    a component
  • CCL20/CCR6 system may be involved in hepatocarcinogenesis
  • INTERACTION
    DNA
    RNA
    small molecule
  • in U937 cell line and bones melanoma
  • repressed by IL-10
  • protein
  • interacting with CCR6 (activating CCR6)
  • cell & other
    REGULATION
    induced by lipopolysaccharide (LPS)
    tumor necrosis factor (TNF)
    interferon-gamma
    phorbol myristate acetate (PMA) in U397 cell line and Bowes melanoma
    repressed by IL-10
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    constitutional     --over  
    in rheumatoid arthritis subchondral bone tissue biopsies
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS