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FLASH GENE

Symbol

CCL20

contributors: mct/npt - updated : 15-04-2008

HGNC name	chemokine (C-C motif) ligand 20
HGNC id	10619

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Scy20

Homologene

FAMILY

intercrine beta family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	having antibacterial activity of great potency
	chemotactic factor attracting lymphocytes and, slightly, neutrophils, but not monocytes
	having the ability to stimulate odontoblast differentiation in addition to role in inflammation
	earlier inducer of osteoclast differentiation by increasing the number of pre-osteoclasts, thus favoring cell fusion and MMP9 release

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

text	inflammatory response

PATHWAY

metabolism

signaling

a component

CCL20/CCR6 system may be involved in hepatocarcinogenesis

INTERACTION

DNA

RNA

small molecule		in U937 cell line and bones melanoma
	repressed by IL-10

protein

interacting with CCR6 (activating CCR6)

cell & other

REGULATION

induced by	lipopolysaccharide (LPS)
		tumor necrosis factor (TNF)
		interferon-gamma
		phorbol myristate acetate (PMA) in U397 cell line and Bowes melanoma

repressed by

IL-10

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in hepatocellular carcinoma constitutional     --over   in rheumatoid arthritis subchondral bone tissue biopsies

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS