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FLASH GENE
Symbol BMP3 contributors: mct - updated : 02-02-2008
HGNC name bone morphogenetic protein 3
HGNC id 1070
Location 4q21.21      Physical location : 81.952.118 - 81.978.684
Synonym name
  • bone morphogenetic protein 3 (osteogenic)
  • osteogenin
  • Synonym symbol(s) BMP-3A, BMP-3
    DNA
    TYPE functioning gene
    STRUCTURE 26.57 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    Physical map
    BMP2K 4q21.23 BMP2 inducible kinase PAQR3 4q21.23 progestin and adipoQ receptor family member III GK2 4q13 glycerol kinase 2 OR7E94P 4q27 olfactory receptor, family 7, subfamily E, member 94 pseudogene GDEP 4q21.1 olfactory receptor, family 7, subfamily E, member 94 pseudogene ANTXR2 4q21.3 anthrax toxin receptor 2 LOC339991 4q21.3 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) PRDM8 4q21 PR domain containing 8 FGF5 4q21 fibroblast growth factor 5 MRPS25P1 4q21.23 mitochondrial ribosomal protein S25 pseudogene MGC35043 4q21.3 hypothetical protein MGC35043 BMP3 4p14-q21 bone morphogenetic protein 3 (osteogenic) PRKG2 4q13.1-q21.1 protein kinase, cGMP-dependent, type II GPIG4 COX5BL1 4cen-q31 cytochrome c oxidase subunit Vb-like 1 LOC345258 4q21.3 similar to bridging integrator 2; bridging integrator-2; breast cancer associated protein BRAP1 HNRPD 4q21.1-q21.2 heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) LOC391672 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) HNRPDL 4q13-q21 heterogeneous nuclear ribonucleoprotein D-like MASA 4q21.3 E-1 enzyme LOC391673 4 similar to protein-tyrosine phosphatase SCD4 4q21.3 stearoyl-CoA desaturase 4 KIAA0905 4q21.3 stearoyl-CoA desaturase 4 THAP9 4q21.3 THAP domain containing 9 DKFZp686L1814 4q21.3 hypothetical protein DKFZp686L1814 COPS4 4q21.21-q21.23 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) PLAC8 4q21.22 placenta-specific 8 LOC391674 4 similar to Aminomethyltransferase, mitochondrial precursor (Glycine cleavage system T protein) (GCVT) CL640 4q21.3 hypothetical protein CL640
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5734 - 472 - 2007 17924656
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     pharynx    
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal eye, fetal lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • TGF-beta-like domain
  • mono polymer homomer , dimer
    isoforms Precursor cleaved at a consensus Arg-X-XArg to yield a C ter mature dimer
    HOMOLOGY
    interspecies homolog to Drosophila decapentaplegic-Vg,DVR family
    Homologene
    FAMILY
  • TGFB superfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • negative regulator of bone density (antagonist of endogenous BMPs)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cartilage and bone formation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BMP2 (antagonist)
  • interacting with TGFB1 (BMP3 stimulates mesenchymal stem cell (MSC) proliferation via the TGF-beta/activin signaling pathway, and both are implicated in regulating MSC proliferation) )
  • cell & other
    REGULATION
    activated by cleaved by subtilisin-like convertases
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in malignant schwannoma
    tumoral     --low  
    in colorectal carcinoma, by promoter hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target attractive target for the future development of molecular blood and/or stool screening tests for the early detection of lesions with neoplastic potential
    ANIMAL & CELL MODELS
    mouse Bmp3-/-have as much trabecular bone as wild type littermates