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FLASH GENE
Symbol BMP3 contributors: mct - updated : 02-02-2008
HGNC name bone morphogenetic protein 3
HGNC id 1070
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TGF-beta-like domain
    • mono polymer homomer , dimer
    isoforms Precursor cleaved at a consensus Arg-X-XArg to yield a C ter mature dimer
    HOMOLOGY
    interspecies homolog to Drosophila decapentaplegic-Vg,DVR family
    Homologene
    FAMILY
  • TGFB superfamily
    • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • negative regulator of bone density (antagonist of endogenous BMPs)
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cartilage and bone formation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BMP2 (antagonist)
  • interacting with TGFB1 (BMP3 stimulates mesenchymal stem cell (MSC) proliferation via the TGF-beta/activin signaling pathway, and both are implicated in regulating MSC proliferation) )
    • cell & other
    REGULATION
    activated by cleaved by subtilisin-like convertases
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in malignant schwannoma
    tumoral     --low  
    in colorectal carcinoma, by promoter hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target attractive target for the future development of molecular blood and/or stool screening tests for the early detection of lesions with neoplastic potential
    ANIMAL & CELL MODELS
    mouse Bmp3-/-have as much trabecular bone as wild type littermates