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FLASH GENE
Symbol BMP3 contributors: mct - updated : 02-02-2008
HGNC name bone morphogenetic protein 3
HGNC id 1070
DNA
TYPE functioning gene
STRUCTURE 26.57 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 5734 - 472 - 2007 17924656
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 pharynx    
Respiratorylung    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal eye, fetal lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TGF-beta-like domain
  • mono polymer homomer , dimer
    isoforms Precursor cleaved at a consensus Arg-X-XArg to yield a C ter mature dimer
    HOMOLOGY
    interspecies homolog to Drosophila decapentaplegic-Vg,DVR family
    Homologene
    FAMILY
  • TGFB superfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • negative regulator of bone density (antagonist of endogenous BMPs)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cartilage and bone formation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BMP2 (antagonist)
  • interacting with TGFB1 (BMP3 stimulates mesenchymal stem cell (MSC) proliferation via the TGF-beta/activin signaling pathway, and both are implicated in regulating MSC proliferation) )
  • cell & other
    REGULATION
    activated by cleaved by subtilisin-like convertases
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in malignant schwannoma
    tumoral     --low  
    in colorectal carcinoma, by promoter hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target attractive target for the future development of molecular blood and/or stool screening tests for the early detection of lesions with neoplastic potential
    ANIMAL & CELL MODELS
    mouse Bmp3-/-have as much trabecular bone as wild type littermates