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FLASH GENE

Symbol

ATG5

contributors: mct/ - updated : 21-10-2010

HGNC name	ATG5 autophagy related 5 homolog (S. cerevisiae)
HGNC id	589

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q21      Physical location : 106.632.353 - 106.773.695
Synonym name	apoptosis specific protein
	APG5 autophagy 5-like (S. cerevisiae)
	autophagy protein 5
	APG5-like
Synonym symbol(s)	ASP, APG5, APG5L

DNA

TYPE	functioning gene
STRUCTURE	141.34 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D6S434 - D6S283 - D6S1692 - ATG5 - D6S278 - RPL3 - D6S1635 - D6S1594 - D6S302 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004849 8 - 3244 NP_004840 32.3 275 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage
cell lines	mammalian cell line
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a high number of acidic residues
	a potential glycosylation site
	potential casein kinase II, protein kinase C and tyrosine kinase sites

conjugated

Other

HOMOLOGY

interspecies	homolog to yeast S .cerevisiae Apg5p
	homolog to murine Apg5l
	homolog to Drosophila CG1643

Homologene

FAMILY

ATG5 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	colocalizes with non-muscle actin

basic FUNCTION	involved in autophagy
	ATG12-ATG5 conjugate has a novel E3-like activity for protein lipidation in autophagy
	ATG5-ATG12 conjugate, a key regulator of the autophagic process, plays an important role in innate antiviral immune responses
	important for B cell survival during development and is differentially required at discrete stages of development in distinct, but closely related, cell lineages
	involved in normal adipocyte differentiation, suggesting an important role of autophagy in adipogenesis
	MAP1LC3B and ATG5 are not required for initiation of autophagy but mediate phagophore expansion and autophagosome formation
	required in antigen presentation by dendritic cells
	with ATG12, ATG2B, ATG9B, are autophagy-related genes, having mononucleotide repeats with seven or more nucleotides

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	highly expressed in apoptotic cells

PATHWAY

metabolism

signaling

involved in ATG5/ATG7-dependent conventional pathway for macroautophagy

a component

conjugation of the K-130 to the G-140 of APG12 is a covalent modification that is essential for autophagy

INTERACTION

DNA

RNA

small molecule

protein	binding to ATG12
	direct interaction between ATG5 and ATG16L1 is crucial to the performance of their roles in autophagy
	single known conjugation target of ATG12

cell & other

binding to isolation membrane

REGULATION

induced by	apoptotic stimuli
		hypoxia

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     led to increased mitochondrial mass in peripheral T cells constitutional     --over   in autoimmune demyelination and multiple sclerosis tumoral somatic mutation       in gastric and colorectal cancers with microsatellite instability

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

All Atg5-null mice died within 1 day of delivery, the survival time of starved Atg5-deficient neonates (approximately 12 hours) was much shorter than that of wildtype mice (approximately 21 hours). Atg5-deficient neonates exhibited reduced amino acid concentrations in plasma and tissues and displayed signs of energy depletion. Neonates adapt to immediate post-birth starvation by inducing autophagy