| 1 | ATG10, ATG12, ATG16L1, ATG5
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| Functional variants of autophagy-related genes are associated with the development of hepatocellular carcinoma.
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| Shen M, Lin L.
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| Life Sci 235:116675. doi: 10.1016/j.lfs.2019.116675. Epub 2019 Jul 21. 2019
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| 2 | ATG5, ATG7, EIF2AK3
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| ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling.
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| Zheng W, Xie W, Yin D, Luo R, Liu M, Guo F.
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| Cell Commun Signal. May 6;17(1):42. doi: 10.1186/s12964-019-0353-3. 2019
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| 3 | ATG10, ATG12, ATG5, ATG7, IFNL2
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| Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135.
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| Zhang MQ, Li JR, Peng ZG, Zhang JP.
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| Front Immunol 9:2176. doi: 10.3389/fimmu.2018.02176. eCollection 2018.
2018
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| 4 | ATF4, ATG5
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| ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure.
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| Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, Liu Z, Ying H, Liu Y, Zhai Q, Chen S, Guo F.
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| Diabetes 66(5):1146-1158. doi: 10.2337/db16-1546. Epub 2017 Feb 17.
2017
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| 5 | ATG5, ATG7
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| Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine.
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| Su LY, Luo R, Liu Q, Su JR, Yang LX, Ding YQ, Xu L, Yao YG.
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| Autophagy 13(9):1496-1511. doi: 10.1080/15548627.2017.1332549. Epub 2017 Jul 19.
2017
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| 6 | ATG5
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| Aging-related Atg5 defect impairs neutrophil extracellular traps formation.
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| Xu F, Zhang C, Zou Z, Fan EKY, Chen L, Li Y, Billiar TR, Wilson MA, Shi X, Fan J.
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| Immunology 151(4):417-432. doi: 10.1111/imm.12740. Epub 2017 May 16.
2017
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| 7 | ATG5, BSN
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| Bassoon Controls Presynaptic Autophagy through Atg5.
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| Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC.
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| Neuron 93(4):897-913.e7. doi: 10.1016/j.neuron.2017.01.026. Erratum in: Neuron. 2018 Feb 7;97(3):727.
2017
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| 8 | ATG5, ATG7
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| Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.2017;. PMID: ;
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| Qiang L, Sample A, Shea CR, Soltani K, Macleod KF, He YY.
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| Autophagy 13(12):2086-2103. doi: 10.1080/15548627.2017.1380757 2017
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| 9 | ATG5, SCAR25
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| Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.
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| Kim M, Sandford E, Gatica D, Qiu Y, Liu X, Zheng Y, Schulman BA, Xu J, Semple I, Ro SH, Kim B, Mavioglu RN, Tolun A, Jipa A, Takats S, Karpati M, Li JZ, Yapici Z, Juhasz G, Lee JH, Klionsky DJ, Burmeister M.
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| Elife 5. pii: e12245. doi: 10.7554/eLife.12245.
2016
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| 10 | ATG12, ATG16L1, ATG5, RACK1
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| RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy.
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| Erbil S, Oral O, Mitou G, Kig C, Durmaz-Timucin E, Guven-Maiorov E, Gulacti F, Gokce G, Dengjel J, Sezerman OU, Gozuacik D.
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| J Biol Chem 291(32):16753-65. doi: 10.1074/jbc.M115.708081. Epub 2016 Jun 20.
2016
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| 11 | ATG5
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| Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis.
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| Li H, Peng X, Wang Y, Cao S, Xiong L, Fan J, Wang Y, Zhuang S, Yu X, Mao H.
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| Autophagy 12(9):1472-86. doi: 10.1080/15548627.2016.1190071. Epub 2016 Jun 15.
2016
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| 12 | ATG16L1, ATG5, TECPR1
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| Swapping of interaction partners with ATG5 for autophagosome maturation.
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| Kim JH, Song HK.
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| BMB Rep 48(3):129-30.
2015
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| 13 | ATG12, ATG16L1, ATG5, TECPR1
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| Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners.
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| Kim JH, Hong SB, Lee JK, Han S, Roh KH, Lee KE, Kim YK, Choi EJ, Song HK.
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| Autophagy 11(1):75-87. doi: 10.4161/15548627.2014.984276.
2015
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| 14 | ATG5, MUL1, ULK1
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| Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy.
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| Li J, Qi W, Chen G, Feng D, Liu J, Ma B, Zhou C, Mu C, Zhang W, Chen Q, Zhu Y.
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| Autophagy 11(8):1216-29. doi: 10.1080/15548627.2015.1017180.
2015
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| 15 | ATG5, ELAVL4
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| The RNA-binding protein HuD regulates autophagosome formation in pancreatic β cells by promoting autophagy-related gene 5 expression.
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| Kim C, Kim W, Lee H, Ji E, Choe YJ, Martindale JL, Akamatsu W, Okano H, Kim HS, Nam SW, Gorospe M, Lee EK.
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| J Biol Chem 289(1):112-21. doi: 10.1074/jbc.M113.474700. Epub 2013 Nov 25.
2014
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| 16 | ATG5
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| Dynamic involvement of ATG5 in cellular stress responses.
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| Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK.
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| Cell Death Dis 5:e1478. doi: 10.1038/cddis.2014.428.
2014
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| 17 | ATG5
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| Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex.
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| Wang S, Li B, Qiao H, Lv X, Liang Q, Shi Z, Xia W, Ji F, Jiao J.
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| EMBO Rep 15(10):1053-61. doi: 10.15252/embr.201338343. Epub 2014 Sep 15.
2014
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| 18 | ATG5
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| The crucial role of Atg5 in cortical neurogenesis during early brain development.
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| Lv X, Jiang H, Li B, Liang Q, Wang S, Zhao Q, Jiao J.
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| Sci Rep 4:6010. doi: 10.1038/srep06010.
2014
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| 19 | ATG5
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| Autophagy is essential for cardiac morphogenesis during vertebrate development.
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| Lee E, Koo Y, Ng A, Wei Y, Luby-Phelps K, Juraszek A, Xavier RJ, Cleaver O, Levine B, Amatruda JF.
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| Autophagy 10(4):572-87. doi: 10.4161/auto.27649. Epub 2014 Jan 14.
2014
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| 20 | ATG5, MYD88
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| Atg5 regulates formation of MyD88 condensed structures and MyD88-dependent signal transduction.
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| Inomata M, Into T, Niida S, Murakami Y.
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| Biochem Biophys Res Commun 437(4):509-14. doi: 10.1016/j.bbrc.2013.06.094. Epub 2013 Jul 2.
2013
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| 21 | ATG5
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| ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy.
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| Maskey D, Yousefi S, Schmid I, Zlobec I, Perren A, Friis R, Simon HU.
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| Nat Commun 4:2130. doi: 10.1038/ncomms3130.
2013
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| 22 | ATG12, ATG5, MAP1LC3B
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| Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan.
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| Mai S, Muster B, Bereiter-Hahn J, Jendrach M.
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| Autophagy 8(1):47-62. doi: 10.4161/auto.8.1.18174. Epub 2012 Jan 1.
2012
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| 23 | ATG12, ATG5, TECPR1
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| A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate.
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| Chen D, Fan W, Lu Y, Ding X, Chen S, Zhong Q.
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| Mol Cell 45(5):629-41. doi: 10.1016/j.molcel.2011.12.036. Epub 2012 Feb 16.
2012
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| 24 | ATG10, ATG12, ATG5, ATG7
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| Structure of the autophagic E2 enzyme Atg10.
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| Hong SB, Kim BW, Kim JH, Song HK.
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| Acta Crystallogr D Biol Crystallogr 68(Pt 10):1409-17. Epub 2012 Sep 18.
2012
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| 25 | ATG5, TECPR1
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| The role of Tecpr1 in selective autophagy as a cargo receptor.
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| Ogawa M, Sasakawa C.
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| Autophagy 7(11):1389-91. doi: 10.4161/auto.7.11.17151. Epub 2011 Nov 1.
2011
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| 26 | ATG5, MAP1LC3B
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| The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
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| Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M, Wouters BG.
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| J Clin Invest 120(1):127-41. doi: 10.1172/JCI40027. Epub 2009 Dec 14.
2010
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| 27 | ATG5
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| In vivo requirement for Atg5 in antigen presentation by dendritic cells.
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| Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A.
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| Immunity 32(2):227-39. Epub 2010 Feb 18.PMID: 20171125 2010
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| 28 | ATG12, ATG3, ATG5
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| ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
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| Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, Debnath J.
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| Cell 142(4):590-600. 2010
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| 29 | ATG5, ATG7
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| Discovery of Atg5/Atg7-independent alternative macroautophagy.
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| Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S.
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| Nature 461(7264):654-8.PMID: 19794493 2009
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| 30 | ATG5
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| Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice.
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| Baerga R, Zhang Y, Chen PH, Goldman S, Jin S.
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| Autophagy 5(8):1118-30. Epub 2009 Nov 2.PMID: 19844159 2009
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| 31 | ATG5
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| Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.
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| Stephenson LM, Miller BC, Ng A, Eisenberg J, Zhao Z, Cadwell K, Graham DB, Mizushima NN, Xavier R, Virgin HW, Swat W.
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| Autophagy 5(5):625-35. Epub 2009 Jul 10.PMID: 19276668 2009
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| 32 | ATG5
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| Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis.
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| Alirezaei M, Fox HS, Flynn CT, Moore CS, Hebb AL, Frausto RF, Bhan V, Kiosses WB, Whitton JL, Robertson GS, Crocker SJ.
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| Autophagy 5(2):152-8. Epub 2009 Feb 5.PMID: 19066443 2009
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| 33 | ATG12, ATG2B, ATG5, ATG9B
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| Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability.
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| Kang MR, Kim MS, Oh JE, Kim YR, Song SY, Kim SS, Ahn CH, Yoo NJ, Lee SH.
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| J Pathol 217(5):702-6.PMID: 19197948 2009
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| 34 | ATG5, CASP8, FADD
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| FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.
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| Bell BD, Leverrier S, Weist BM, Newton RH, Arechiga AF, Luhrs KA, Morrissette NS, Walsh CM.
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| Proc Natl Acad Sci U S A 105(43):16677-82. Epub 2008 Oct 22.
2008
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| 35 | ATG5
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| The autophagy gene ATG5 plays an essential role in B lymphocyte development.
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| Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW 4th.
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| Autophagy 4(3):309-14. Epub 2007 Dec 24.PMID: 18188005 2008
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| 36 | ATG16L1, ATG5
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| Structure of Atg5.Atg16, a complex essential for autophagy.
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| Matsushita M, Suzuki NN, Obara K, Fujioka Y, Ohsumi Y, Inagaki F.
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| J Biol Chem 282(9):6763-72. Epub 2006 Dec 27.PMID: 17192262 2007
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| 37 | ATG12, ATG5, GABARAPL2
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| The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy.
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| Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F, Ohsumi Y.
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| J Biol Chem 282(52):37298-302. Epub 2007 Nov 6.PMID: 17986448 2007
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| 38 | ATG12, ATG5
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| The Atg5 Atg12 conjugate associates with innate antiviral immune responses.
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| Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki K, Okuda K.
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| Proc Natl Acad Sci U S A 104(35):14050-5. Epub 2007 Aug 20.PMID: 17709747 2007
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| 39 | ATG5
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| [Bioinformatics analysis of autophagy 5 gene structure]
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| Chen Y, Peng XZ, Piao YJ.
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| Yi Chuan Xue Bao 28(11):1077-84. Chinese. 2001
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| 40 | ATG5
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| Assignment(1) of the yeast APG5 human homologue APG5L to chromosome band 6q21 by fluorescence in situ hybridisation.
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| Schmeiser K, Armstrong S, Hammond EM, Grand RJ.
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| Cytogenet Cell Genet 87(3-4):213-214. 1999
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| 41 | ATG5
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| Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast.
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| Hammond EM, et al.
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| FEBS Lett 425(3):391-5 1998
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| 42 | ATG12, ATG5
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| A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy.
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| Mizushima N, et al.
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| J Biol Chem 273(51):33889-92 1998
|