Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ANKRD6 contributors: mct - updated : 06-06-2014
HGNC name ankyrin repeat domain 6
HGNC id 17280
Location 6q15      Physical location : 90.142.896 - 90.343.402
Synonym name diversin
Synonym symbol(s) KIAA0957
DNA
TYPE functioning gene
STRUCTURE 200.66 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ORC3L 6q14.3-16.3 origin recognition complex, subunit 3-like (yeast) C6orf166 6q15 chromosome 6 open reading frame 166 SPACA1 6q16.1 sperm acrosome associated 1 CNR1 6q14-q15 cannabinoid receptor 1 (brain) LOC391951 6 similar to ribosomal protein S14 ACTBP8 6q13 actin, beta pseudogene 8 RNGTT 6q16 RNA guanylyltransferase and 5'-phosphatase HCP16 6q15 cytochrome c, somatic pseudogene PNRC1 6q16.1 proline-rich nuclear receptor coactivator 1 SRrp35 6q16.1 serine-arginine repressor protein (35 kDa) ACY1L2 6q16.1 aminoacylase 1-like 2 GABRR1 6q13-q15.3 gamma-aminobutyric acid (GABA) receptor, rho 1 GABRR2 6q14-q16.3 gamma-aminobutyric acid (GABA) receptor, rho 2 UBE2J1 6q16.1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) RRAGD 6q15-q16 Ras-related GTP binding D ANKRD6 6q14.2-q16.1 ankyrin repeat domain 6 DJ122O8.2 6q14.2-q16.1 hypothetical protein dJ122O8.2 MDN1 6q15 MDN1, midasin homolog (yeast) CASP8AP2 6q16.1 CASP8 associated protein 2 CX62 6q15-q16 connexin 62 LOC285793 6q16.1 hypothetical LOC285793 BACH2 6q15 BTB and CNC homology 1, basic leucine zipper transcription factor 2 MAP3K7 6q16.1-q16.3 mitogen-activated protein kinase kinase kinase 7
RNA
TRANSCRIPTS type messenger
text alternative splicing
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 5355 - 727 - 2006 1703276
15 - 5250 - 692 - 2006 1703276
16 - 5738 - 727 - 2006 1703276
12 - 4961 - 663 - 2006 1703276
- - 5340 - 722 - 2006 1703276
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrineneuroendocrinepituitary  highly
 thyroid   highly
Nervousbrain    
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight ANK repeats, involved in protein-protein interaction
  • two coiled-coil regions
  • several nuclear localization signals
  • HOMOLOGY
    interspecies ortholog to the Drosophila PCP protein Diego
    intraspecies homolog to ankyrin
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    text
  • intermediate filament protein
  • translocates to the nucleus
  • localizes to the centrosome
  • basic FUNCTION
  • regulates heart formation and gastrulation movements in development
  • acting as a molecular switch, which suppresses Wnt signals mediated by the canonical beta-catenin pathway and stimulates signaling via JNK
  • acts as a molecular switch that blocks beta-catenin-dependent and promotes beta-catenin-independent WNT signaling
  • ANKRD6, and MLLT3 block canonical WNT signaling; however, this occurs independently of each other, and does not require nuclear ANKRD6
  • centrosomal localization of ANKRD6 is crucial for its function in Wnt signaling
  • involvement of ANKRD6 in processes that are related to the acquisition of cell polarity and require ciliary functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    player of WNT signaling, with DVL1, in embryogenesis
    a component essential component of the Wnt-signaling pathway and
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DVL1
  • in the nucleus, interacts with the transcription factor MLLT3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS