Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ANKRD6 contributors: mct - updated : 06-06-2014
HGNC name ankyrin repeat domain 6
HGNC id 17280
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight ANK repeats, involved in protein-protein interaction
  • two coiled-coil regions
  • several nuclear localization signals
  • HOMOLOGY
    interspecies ortholog to the Drosophila PCP protein Diego
    intraspecies homolog to ankyrin
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    text
  • intermediate filament protein
  • translocates to the nucleus
  • localizes to the centrosome
  • basic FUNCTION
  • regulates heart formation and gastrulation movements in development
  • acting as a molecular switch, which suppresses Wnt signals mediated by the canonical beta-catenin pathway and stimulates signaling via JNK
  • acts as a molecular switch that blocks beta-catenin-dependent and promotes beta-catenin-independent WNT signaling
  • ANKRD6, and MLLT3 block canonical WNT signaling; however, this occurs independently of each other, and does not require nuclear ANKRD6
  • centrosomal localization of ANKRD6 is crucial for its function in Wnt signaling
  • involvement of ANKRD6 in processes that are related to the acquisition of cell polarity and require ciliary functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    player of WNT signaling, with DVL1, in embryogenesis
    a component essential component of the Wnt-signaling pathway and
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DVL1
  • in the nucleus, interacts with the transcription factor MLLT3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS