basic FUNCTION
| regulates heart formation and gastrulation movements in development |
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acting as a molecular switch, which suppresses Wnt signals mediated by the canonical beta-catenin pathway and stimulates signaling via JNK |
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acts as a molecular switch that blocks beta-catenin-dependent and promotes beta-catenin-independent WNT signaling |
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ANKRD6, and MLLT3 block canonical WNT signaling; however, this occurs independently of each other, and does not require nuclear ANKRD6 |
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centrosomal localization of ANKRD6 is crucial for its function in Wnt signaling |
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involvement of ANKRD6 in processes that are related to the acquisition of cell polarity and require ciliary functions |